2-(3-Hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives as potential multifunctional anti-Alzheimer’s agents
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DOI: 10.1007/s00044-021-02725-6
Abstract: A series of 2-(3-hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives were designed as potential multifunctional agents against Alzheimer’s disease. The twelve derivatives were synthesized and evaluated with various biological activities. In vitro, biological assays showed that most of… read more here.
Keywords: benzo isothiazol; mannich base; base derivatives; hydroxybenzyl benzo ... See more keywords
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
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DOI: 10.1016/j.ejmech.2016.12.009
Abstract: A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good… read more here.
Keywords: mannich base; alzheimer disease; aurone mannich; base derivatives ... See more keywords
Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.08.004
Abstract: &NA; Targeting protein aggregation for the therapy of neurodegenerative diseases remains elusive for medicinal chemists, despite a number of small molecules known to interfere in amyloidogenesis, particularly of amyloid beta (A&bgr;) protein. Starting from previous… read more here.
Keywords: mannich base; bgr; methoxyisatin isopropylphenyl; isopropylphenyl hydrazone ... See more keywords
Catalytic promiscuity of a copper(II)-Mannich base complex having unprecedented radical pathway in catecholase activity
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DOI: 10.1016/j.ica.2020.119480
Abstract: Abstract A flexible single-side Mannich base ligand namely 4-(tert-butyl)-2-((ethyl(2-hydroxyethyl)amino)methyl)phenol (H2L) having O, N, O donor sites has been designed and synthesized using 4-(tert-butyl)phenol, formaldehyde and 2-(ethylamino)ethanol as precursors with the view to prepare polynuclear complex(s).… read more here.
Keywords: mannich base; copper; complex; tert butyl ... See more keywords
Kinetic studies of the impact of thiocyanate moiety on the catalytic properties of Cu(II) and Fe(III) complexes of a new Mannich base
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DOI: 10.1016/j.molstruc.2017.12.011
Abstract: Abstract Four new metal complexes of a novel Mannich base 5-methyl-2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)phenol (HL) have been prepared. The compounds were characterized by an array of analytical and spectroscopic methods including Nuclear Magnetic Resonance, Infra-red and UV–Visible spectroscopy.… read more here.
Keywords: mannich base; kinetic studies; studies impact; base ... See more keywords
Polymorphism of a new Mannich base - [-4-methyl-2-((4-(4-nitrophenyl)piperazin-1-yl)methyl)phenol]
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DOI: 10.1016/j.molstruc.2018.01.068
Abstract: Abstract Two polymorphs (forms I and II) of a new Mannich base 4-methyl-2-((4-(4-nitrophenyl)piperazin-1-yl)methyl)phenol have been isolated and characterized by single crystal and powder (experimental and theoretical) X-ray diffraction, thermal analysis (differential scanning calorimetry), Fourier transform… read more here.
Keywords: methyl; mannich base; base methyl; spectroscopy ... See more keywords
Synthesis, crystal structure, experimental and theoretical studies of corrosion inhibition of 2-((4-(2-hydroxy-4-methylbenzyl)piperazin-1-yl)methyl)-5-methylphenol – A Mannich base
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DOI: 10.1016/j.molstruc.2020.128539
Abstract: Abstract A new Mannich base; 2-((4-(2-hydroxy-4-methylbenzyl)piperazin-1-yl)methyl)-5-methylphenol (HMP) was synthesized, characterized by elemental analysis, UV/Vis, 1H and 13C NMR spectroscopy, and examined as an inhibitor for the corrosion of a mild steel surface in 0.2 M sulphuric… read more here.
Keywords: mannich base; hydroxy methylbenzyl; structure; piperazin methyl ... See more keywords
Synthesis, spectra, electronic structure, molecular docking and cytotoxicity investigation on 2-(piperidin-1-ylmethyl)-isoindoline-1,3-dione – A Mannich base system
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DOI: 10.1016/j.molstruc.2020.129151
Abstract: Abstract A Mannich base molecule of 2-(piperidin-1-ylmethyl)isoindoline-1,3-dione (PPF) has been synthesized using Mannich base condensation reaction. The molecular geometry of PPF molecule was optimized by B3LYP/6-311G(d,p) basis set. The vibrational frequencies have been assigned with… read more here.
Keywords: piperidin ylmethyl; mannich base; isoindoline dione; base ... See more keywords
In vitro antileishmanial activity and iron superoxide dismutase inhibition of arylamine Mannich base derivatives
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DOI: 10.1017/s0031182017001123
Abstract: SUMMARY Leishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs.… read more here.
Keywords: mannich base; iron superoxide; superoxide dismutase; dismutase inhibition ... See more keywords
Nuclearity dependent solvent contribution to the catechol oxidase activity of novel copper(II) complexes derived from Mannich-base ligand platforms: Synthesis, crystal structure and mechanism
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DOI: 10.1039/c7nj00425g
Abstract: A set of tetra- and dinuclear copper(II) complexes, [Cu4(L1)(μ-O)(OAc)4] (1), [Cu2(L2)2](ClO4)2 (2), [Cu2(L2)2(OAc)2] (3), [Cu2(L2)2(Br)2] (4) and [Cu2(L2)2(Cl)2] (5), were synthesized from two Mannich-base ligands HL1 and HL2, where HL1 = 2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-methylphenol and HL2 =… read more here.
Keywords: mannich base; copper complexes; cu2; water ... See more keywords
Rare azido and hydroxido bridged tetranuclear Co(II) complexes of a polynucleating Mannich base ligand with a defect dicubane core: structures, magnetism and phenoxazinone synthase like activity
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DOI: 10.1039/c8nj04750b
Abstract: Three novel tetranuclear cobalt(II) complexes [Co4L2(μ1,1,1-N3)2(N3)2] (1), [Co4L2(μ3-OH)2(NCS)2]·4CH3CN (2) and [Co4L2(μ3-OH)2(NCSe)2]·2CH3CN (3) have been synthesized on reacting a Mannich base ligand, N,N′-dimethyl-N,N′-bis(2-hydroxy-3-methoxy-5-methylbenzyl)ethylenediamine (H2L), with cobalt(II) acetate tetrahydrate in the presence of azide, thiocyanate and selenocynate… read more here.
Keywords: mannich base; synthase like; base ligand; activity ... See more keywords