Enantioselective Mannich Reaction Employing 1,3,5‐Triaryl‐1,3,5‐triazinanes Catalyzed by Chiral‐at‐Metal Rhodium Complexes
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DOI: 10.1002/ejoc.201700463
Abstract: Chiral-at-metal Rh(III) complexes catalyzed highly efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes is developed, affording the corresponding adducts in 81-99% yields with up to >99% enantioselectivities. This protocol performs with 0.1 mol %… read more here.
Keywords: chiral metal; enantioselective mannich; mannich reaction; reaction employing ... See more keywords
Nanostructured Zirconium Pyrophosphate Catalyzed Diastereoselective Synthesis of β-Amino Ketones via One-Pot Three-Component Mannich Reaction
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Letters"
DOI: 10.1007/s10562-017-2264-5
Abstract: In this study, ZrP2O7 catalytic nanomaterials were prepared by co-precipitation and polyvinylpyrrolidone assisted methods. These nanomaterials were structurally characterized by XRD, N2 adsorption/desorption, TGA, SEM and TEM microscopy techniques. This study investigated the application of… read more here.
Keywords: mannich reaction; amino; three component; one pot ... See more keywords
Ultrasound-assisted synthesis of β-amino ketones via a Mannich reaction catalyzed by Fe3O4 magnetite nanoparticles as an efficient, recyclable and heterogeneous catalyst
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2012.11.018
Abstract: Abstract In this study, magnetite nanoparticles (Fe 3 O 4 MNPs) were introduced as a heterogeneous novel catalyst for ultrasound-assisted stereoselective synthesis of β -amino carbonyl during Mannich reaction. For this propose, MNPs with particle… read more here.
Keywords: mannich reaction; catalyst; reaction; synthesis amino ... See more keywords
Amination of biorefinery technical lignins using Mannich reaction synergy with subcritical ethanol depolymerization.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.09.012
Abstract: The alcoholic depolymerization and Mannich reaction were conducted to improve the chemical activity of biorefinery technical lignins and introduce amino groups into lignins, respectively. To understand the chemical structural transformations and examine the reaction mechanism,… read more here.
Keywords: mannich reaction; depolymerization; amination biorefinery; biorefinery technical ... See more keywords
Amination of biorefinery technical lignin by Mannich reaction for preparing highly efficient nitrogen fertilizer.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.01.076
Abstract: To develop a novel lignin-based highly efficient nitrogen fertilizer, the amination of the biorefinery technical lignin was conducted by Mannich reaction synergy with phenolation pretreatment. Subsequently, the structural transformations of lignin samples and the reaction… read more here.
Keywords: nitrogen; highly efficient; mannich reaction; efficient nitrogen ... See more keywords
Radical cyclisation studies of β-nitroamines from the nitro-Mannich reaction
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DOI: 10.1016/j.tet.2018.06.022
Abstract: Abstract A range of novel β-nitroacetamides with an alkenyl- or alkynyl tether were synthesized using the deprotonative or conjugate addition nitro-Mannich reaction. They were subjected to radical denitration-cyclisation with a 10 equivalent excess of tributyltin… read more here.
Keywords: mannich reaction; cyclisation studies; nitro mannich; radical cyclisation ... See more keywords
Asymmetric organocatalytic direct Mannich reaction of acetylacetone and isatin derived ketimines: Low catalyst loading in chiral cinchona-squaramides
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.081
Abstract: Abstract A highly enantioselective synthesis of 3-amino-2-oxindoles by direct Mannich reaction between acetylacetone and N-carbamoyl isatin ketimine has been described herein. Corresponding chiral adducts were obtained in high yields (up to 98%) and with excellent… read more here.
Keywords: reaction acetylacetone; catalyst loading; mannich reaction; direct mannich ... See more keywords
Mannich reaction of pyrrole and dimethylpyrrole with monoamines and diamines
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DOI: 10.1016/j.tetlet.2019.151247
Abstract: Abstract The Mannich reaction of pyrrole with ethylenediamine dihydrochloride and formaldehyde gave two compounds: N1,N1,N2,N2-tetrakis(pyrrol-2-ylmethyl)ethane-1,2-diamine 1 and 1,3-bis(pyrrol-2-ylmethyl)imidazolidine 2 in poor yields. Conversely, the reaction of pyrrole with propylenediamine dihydrochloride afforded macrocyclic compound 3 containing… read more here.
Keywords: pyrrole dimethylpyrrole; mannich reaction; reaction; reaction pyrrole ... See more keywords
Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines.
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DOI: 10.1021/acs.orglett.0c01578
Abstract: A catalytic asymmetric umpolung cross-Mannich reaction of cyclic ketimines is realized. This protocol provides an efficient methodology for the facile synthesis of chiral vicinal tetrasubstituted diamines in high yields with excellent chemo-, regio-, diastereo-, and… read more here.
Keywords: mannich reaction; reaction cyclic; cyclic ketimines; umpolung cross ... See more keywords
Total Synthesis of Strempeliopidine and Non-Natural Stereoisomers through a Convergent Petasis Borono-Mannich Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13146
Abstract: Strempeliopidine is a member of the monoterpenoid bisindole alkaloid family, a class of natural products that have been shown to elicit an array of biological responses including modulating protein-protein interactions in human cancer cells. Our… read more here.
Keywords: borono mannich; synthesis strempeliopidine; petasis borono; mannich reaction ... See more keywords
Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
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DOI: 10.1038/s41467-019-09750-5
Abstract: Chiral aziridines are structure units found in many biologically active compounds and are important building blocks in organic synthesis. Herein, by merging nucleophilic generation through copper(I)-catalyzed decarboxylation and activation of poorly electrophilic 2H-azirines through protonation… read more here.
Keywords: mannich reaction; acidic activation; decarboxylative mannich; activation ... See more keywords