Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.12.012
Abstract: Abstract Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported. read more here.
Keywords: ethylacetoacetate dimethyl; dimethyl fluoromalonate; fluoromalonate ester; component mannich ... See more keywords
Organocatalytic Enantioselective γ-Position-Selective Mannich Reactions of β-Ketocarbonyl Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c02433
Abstract: Catalytic asymmetric Mannich reactions of β-ketocarbonyl derivatives (such as β-ketoesters and (2-oxopropyl)phosphonate), resulting in the formation of a C–C bond at the γ-position of the β-ketocarbonyl derivatives with high enantioselectivities, are reported. The bond formation… read more here.
Keywords: reactions ketocarbonyl; ketocarbonyl derivatives; organocatalytic enantioselective; enantioselective position ... See more keywords
Tuning the Reactivity of Ketones through Unsaturation: Construction of Cyclic and Acyclic Quaternary Stereocenters via Zn-ProPhenol Catalyzed Mannich Reactions
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DOI: 10.1021/acscatal.8b04685
Abstract: Introduction of unsaturation adjacent to the carbonyl drastically improves the reactivity of the Zn-ProPhenol catalyzed Mannich reactions between N-carbamoyl imines and a-branched ketones. Despite only a small change in the substrate acidity, the bimetallic catalyst… read more here.
Keywords: cyclic acyclic; acyclic quaternary; catalyzed mannich; quaternary stereocenters ... See more keywords
Borane-Catalyzed Direct Asymmetric Vinylogous Mannich Reactions of Acyclic α,β-Unsaturated Ketones.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00006
Abstract: Herein, we report that, by using chiral bicyclic bisborane catalysts, we have achieved the first highly regio-, diastereo-, and enantioselective direct asymmetric vinylogous Mannich reactions of acyclic α,β-unsaturated ketones. The strong Lewis acidity and steric… read more here.
Keywords: acyclic unsaturated; direct asymmetric; asymmetric vinylogous; reactions acyclic ... See more keywords
Brønsted–Lewis dual acidic ionic liquid immobilized on mesoporous silica materials as an efficient cooperative catalyst for Mannich reactions
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c7nj02541f
Abstract: Novel mesoporous silica supported ILs have been prepared and successfully applied as a heterogeneous catalyst in Mannich reactions. The excellent recyclability of the supported catalyst, mild reaction conditions, good to excellent yields, low catalyst loading,… read more here.
Keywords: nsted lewis; mesoporous silica; catalyst mannich; mannich reactions ... See more keywords
Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-[(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl]cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions
Sign Up to like & getrecommendations! Published in 2018 at "Revista De Chimie"
DOI: 10.37358/rc.17.12.5991
Abstract: http://www.revistadechimie.ro 2845 Mannich reactions are key tools for chemist to construct carbon-carbon relationship in the field of present synthetic organic chemistry [1-3]. The condensation product of aldehyde, amine and an active hydrogen compound is called… read more here.
Keywords: mannich base; chemistry; mannich bases; mannich reactions ... See more keywords