Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.0891
Abstract: Key Points Question How commonly are hyperosmolar therapies used in the management of severe traumatic brain injury in children, and which agent—mannitol or hypertonic saline solution—is associated with greater decreases in intracranial pressure (ICP) and/or… read more here.
Keywords: traumatic brain; mannitol; brain injury; hypertonic saline ... See more keywords
Intra-Vial Heterogeneity in Physical Form of Mannitol in Colyophilized Binary Systems
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2499-x
Abstract: AbstractPurposeTo study spatial heterogeneity in phase composition when mannitol is co-lyophilized with non-crystallizing lyoprotectant, such as sucrose or trehalose. To study the influence of formulation composition and processing conditions on the extent of mannitol hemihydrate… read more here.
Keywords: vial heterogeneity; mhh; phase; heterogeneity ... See more keywords
Intraoperative mannitol during robotic-assisted-laparoscopic partial nephrectomy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Robotic Surgery"
DOI: 10.1007/s11701-018-0868-4
Abstract: Mannitol is routinely used during partial nephrectomies due to its renoprotective properties. With minimally invasive techniques, the need for mannitol has been questioned. Robotic-assisted laparoscopic partial nephrectomy (RALPN) has been shown to decrease warm ischemia… read more here.
Keywords: partial nephrectomy; laparoscopic partial; mannitol; robotic assisted ... See more keywords
Phase III Trial of Intravenous Mannitol Versus Placebo During Nephron-sparing Surgery: Post Hoc Analysis of 3-yr Outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "European urology focus"
DOI: 10.1016/j.euf.2019.04.003
Abstract: Our recently reported phase III trial demonstrated that patients undergoing nephron-sparing surgery (NSS) with an estimated glomerular filtration rate (eGFR) of ≥45 ml/min/1.73 m2 who received mannitol had no improvement in renal function at 6 mo… read more here.
Keywords: surgery; trial; nephron sparing; mannitol ... See more keywords
Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Food research international"
DOI: 10.1016/j.foodres.2020.109638
Abstract: Recently, the term healthy lifestyle connected to low-calorie diets, although it is not possible to get rid of added sugars as a source of energy, despite the close relation of added sugars to some diseases… read more here.
Keywords: mannitol dehydrogenases; mannitol; hyperthermostable mannitol; archaeal hyperthermostable ... See more keywords
Particle engineered mannitol for carrier-based inhalation - a serious alternative?
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118901
Abstract: In dry powder inhalation (DPI), larger carrier particles, typically lactose, are blended with micronised active pharmaceutical ingredient (API) particles to improve handling, processability and inhalable fraction. Alternative carrier materials were researched for years, but did… read more here.
Keywords: particle engineered; mannitol carrier; mannitol; engineered mannitol ... See more keywords
Twin-screw granulation and high-shear granulation: the influence of mannitol grade on granule and tablet properties.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119890
Abstract: Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice… read more here.
Keywords: granulation; twin screw; mannitol; high shear ... See more keywords
Bortezomib Aqueous Solubility in the Presence and Absence of D-Mannitol: A Clarification with Formulation Implications.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.10.012
Abstract: The solubility of bortezomib, a boronic acid, in water and normal saline is often misquoted in the literature. Here we confirm that bortezomib equilibrium solubility in water and normal saline is 0.59 ± 0.07 and… read more here.
Keywords: presence; mannitol; aqueous solubility; formulation ... See more keywords
Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107994119
Abstract: SignificanceMannitol biosynthesis is essential for Acinetobacter baumannii to cope with osmotic stress. Currently, only Pseudomonas putida, Acinetobacter baylyi, and A. baumannii are able to de novo synthesize mannitol by a structurally unique bifunctional mannitol-1-phosphate dehydrogenase/phosphatase… read more here.
Keywords: acinetobacter baumannii; mannitol; helix loop; helix ... See more keywords
Is mannitol the treatment of choice for patients with ciguatera fish poisoning?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Toxicology"
DOI: 10.1080/15563650.2017.1327664
Abstract: Abstract Context: Ciguatera fish poisoning arises primarily from consumption of carnivorous reef fish caught in tropical and sub-tropical waters. Ciguatoxins, a class of tasteless, heat-stable, polycyclic toxins produced by dinoflagellates, accumulate through the food chain… read more here.
Keywords: ciguatera fish; treatment; fish poisoning; mannitol ... See more keywords
A Novel In-Line Delivery System to Administer Dry Powder Mannitol to Mechanically Ventilated Patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2016.1320
Abstract: BACKGROUND Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and… read more here.
Keywords: dry powder; line; delivery; mannitol ... See more keywords