Amphiphilic mannose-6-phosphate glycopolypeptide-based bioactive and responsive self-assembled nanostructures for controlled and targeted lysosomal cargo delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm01469a
Abstract: Receptors of carbohydrate mannose-6-phosphate (M6P) are overexpressed in specific cancer cells (such as breast cancer) and are also involved in the trafficking of mannose-6-phosphate labeled proteins exclusively onto lysosomes via cell surface M6P receptor (CI-MPR)… read more here.
Keywords: based bioactive; mannose phosphate; phosphate glycopolypeptide; phosphate ... See more keywords
Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc06169g
Abstract: Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be… read more here.
Keywords: dual enzyme; phosphate based; responsive mannose; mannose phosphate ... See more keywords
Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203518119
Abstract: Significance Lysosomes are cellular organelles containing a variety of degradative enzymes. The protein N-acetylglucosamine-1-phosphotransferase (GNPT) is responsible for directing these enzymes to be delivered to lysosomes. Genetic mutations in GNPT cause the diseases mucolipidosis types… read more here.
Keywords: phosphate pathway; enzyme glcnac; mannose phosphate; structures mannose ... See more keywords
LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2167375
Abstract: ABSTRACT Vertebrate cells rely on mannose-6-phosphate (M6P) modifications to deliver most lumenal hydrolases to the lysosome. As a critical trafficking signal for lysosomal enzymes, the M6P biosynthetic pathway has been thoroughly investigated. However, its regulatory… read more here.
Keywords: phosphate m6p; pathway; lyset tmem251; mannose phosphate ... See more keywords
LYSET/TMEM251- a novel key component of the mannose-6-phosphate pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2167376
Abstract: ​​Degradation of macromolecules delivered to lysosomes by processes such as autophagy or endocytosis is crucial for cellular function. Lysosomes require more than 60 soluble hydrolases in order to catabolize such macromolecules. These soluble hydrolases are… read more here.
Keywords: phosphate; lyset tmem251; mannose phosphate; glcnac phosphotransferase ... See more keywords
Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2079719
Abstract: ABSTRACT A lysosome, an acidic membrane-bound organelle, contains hydrolytic enzymes to digest macromolecules for recycling. Many lysosomal enzymes (LEs) traffic to the lysosome through the mannose-6-phosphate (M6P)-dependent pathway. Some mannose residues of high-mannose type N-glycans… read more here.
Keywords: mannose phosphate; replacement therapy; lysosome; enzyme replacement ... See more keywords
Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1163638
Abstract: Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies. Ginsenoside Rg1 is… read more here.
Keywords: mannose phosphate; fatigue; cfs rats; taurine mannose ... See more keywords
The Synthesis of Mannose-6-Phosphate Using Polyphosphate-Dependent Mannose Kinase
Sign Up to like & getrecommendations! Published in 2019 at "Catalysts"
DOI: 10.3390/catal9030250
Abstract: Mannose-6-phosphate (M6P) is involved in many metabolic pathways in life, and it has important applications in the treatment of diseases. This study explored a cost-effective enzyme catalytic synthesis method of M6P, using polyphosphate-dependent mannose kinase… read more here.
Keywords: using polyphosphate; mannose kinase; polyphosphate dependent; mannose phosphate ... See more keywords