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   Articles with "mannose phosphate" as a keyword



Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells

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recommendations! Published in 2024 at "Journal of Proteome Research"

DOI: 10.1021/acs.jproteome.4c00705

Abstract: Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cells… read more here.

Keywords: proteome degradome; rearrangement proteome; phosphate isomerase; mannose phosphate ... See more keywords

Amphiphilic mannose-6-phosphate glycopolypeptide-based bioactive and responsive self-assembled nanostructures for controlled and targeted lysosomal cargo delivery.

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recommendations! Published in 2020 at "Biomaterials science"

DOI: 10.1039/d0bm01469a

Abstract: Receptors of carbohydrate mannose-6-phosphate (M6P) are overexpressed in specific cancer cells (such as breast cancer) and are also involved in the trafficking of mannose-6-phosphate labeled proteins exclusively onto lysosomes via cell surface M6P receptor (CI-MPR)… read more here.

Keywords: based bioactive; mannose phosphate; phosphate glycopolypeptide; phosphate ... See more keywords

Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery.

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recommendations! Published in 2020 at "Chemical communications"

DOI: 10.1039/d0cc06169g

Abstract: Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be… read more here.

Keywords: dual enzyme; phosphate based; responsive mannose; mannose phosphate ... See more keywords

Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2203518119

Abstract: Significance Lysosomes are cellular organelles containing a variety of degradative enzymes. The protein N-acetylglucosamine-1-phosphotransferase (GNPT) is responsible for directing these enzymes to be delivered to lysosomes. Genetic mutations in GNPT cause the diseases mucolipidosis types… read more here.

Keywords: phosphate pathway; enzyme glcnac; mannose phosphate; structures mannose ... See more keywords

LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway

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recommendations! Published in 2023 at "Autophagy"

DOI: 10.1080/15548627.2023.2167375

Abstract: ABSTRACT Vertebrate cells rely on mannose-6-phosphate (M6P) modifications to deliver most lumenal hydrolases to the lysosome. As a critical trafficking signal for lysosomal enzymes, the M6P biosynthetic pathway has been thoroughly investigated. However, its regulatory… read more here.

Keywords: phosphate m6p; pathway; lyset tmem251; mannose phosphate ... See more keywords

LYSET/TMEM251- a novel key component of the mannose-6-phosphate pathway.

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recommendations! Published in 2023 at "Autophagy"

DOI: 10.1080/15548627.2023.2167376

Abstract: ​​Degradation of macromolecules delivered to lysosomes by processes such as autophagy or endocytosis is crucial for cellular function. Lysosomes require more than 60 soluble hydrolases in order to catabolize such macromolecules. These soluble hydrolases are… read more here.

Keywords: phosphate; lyset tmem251; mannose phosphate; glcnac phosphotransferase ... See more keywords

Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras

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recommendations! Published in 2022 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2022.2079719

Abstract: ABSTRACT A lysosome, an acidic membrane-bound organelle, contains hydrolytic enzymes to digest macromolecules for recycling. Many lysosomal enzymes (LEs) traffic to the lysosome through the mannose-6-phosphate (M6P)-dependent pathway. Some mannose residues of high-mannose type N-glycans… read more here.

Keywords: mannose phosphate; replacement therapy; lysosome; enzyme replacement ... See more keywords

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1163638

Abstract: Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies. Ginsenoside Rg1 is… read more here.

Keywords: mannose phosphate; fatigue; cfs rats; taurine mannose ... See more keywords

The Synthesis of Mannose-6-Phosphate Using Polyphosphate-Dependent Mannose Kinase

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recommendations! Published in 2019 at "Catalysts"

DOI: 10.3390/catal9030250

Abstract: Mannose-6-phosphate (M6P) is involved in many metabolic pathways in life, and it has important applications in the treatment of diseases. This study explored a cost-effective enzyme catalytic synthesis method of M6P, using polyphosphate-dependent mannose kinase… read more here.

Keywords: using polyphosphate; mannose kinase; polyphosphate dependent; mannose phosphate ... See more keywords