Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C‐mannosylation
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13561
Abstract: C‐mannosylation is a rare type of protein glycosylation whereby a single mannose is added to the first tryptophan in the consensus sequence Trp‐Xaa‐Xaa‐Trp/Cys (in which Xaa represents any amino acid). Its consensus sequence is mainly… read more here.
Keywords: vitelline membrane; vmo1; membrane outer; mannosylation ... See more keywords
C-mannosylated tryptophan-containing WSPW peptide binds to actinin-4 and alters E-cadherin subcellular localization in lung epithelial-like A549 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.10.007
Abstract: The Trp-x-x-Trp (W-x-x-W) peptide motif, a consensus site for C-mannosylation, is the functional motif in cytokine type I receptors or thrombospondin type I repeat (TSR) superfamily proteins. W-x-x-W motifs are important for physiological and pathological… read more here.
Keywords: a549 cells; wspw peptides; mannosylation; localization ... See more keywords
Yeast- and antibody-based tools for studying tryptophan C-mannosylation
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DOI: 10.1038/s41589-020-00727-w
Abstract: Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. The prevalence and biological functions of this modification are poorly understood, with progress in the field hampered by a dearth of… read more here.
Keywords: antibody based; tryptophan mannosylation; yeast antibody; mannosylation ... See more keywords
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302584120
Abstract: Mutations in the TMEM260 gene cause structural heart defects and renal anomalies syndrome, but the function of the encoded protein remains unknown. We previously reported wide occurrence of O-mannose glycans on extracellular immunoglobulin, plexin, transcription… read more here.
Keywords: ipt domains; protein specific; mannosyltransferase; gene ... See more keywords
Abstract C024: Ribitol enhancesO-mannosylation of α-DG in breast cancer cells
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DOI: 10.1158/1535-7163.targ-19-c024
Abstract: O-mannosylation of a-dystroglycan (α-DG) is an important modification in most tissues in mammals and plays diverse roles, from acting as viral receptors to neuronal development. The glycosylation produces a laminin-binding glycan (matriglycan) identified in nearly… read more here.
Keywords: ribitol; mannosylation; cancer cells; cancer ... See more keywords
Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines.
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DOI: 10.3892/ol.2017.6465
Abstract: C-mannosylation is a unique type of protein glycosylation with a mannose attached to the tryptophan residue via the C-C linkage. Our previous study revealed that dpy-19 like 3 (DPY19L3) acts as a C-mannosyltransferase in human… read more here.
Keywords: mannosylation; cell lines; rpesp; expression levels ... See more keywords