Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27742
Abstract: The development of highly productive, genetically stable manufacturing cell lines is on the critical path to IND filing for protein‐based biologic drugs. Here, we describe the Leap‐In Transposase® platform, a novel transposon‐based mammalian (e.g., Chinese… read more here.
Keywords: cell lines; manufacturing cell; transposon; cell ... See more keywords
Strategies for manufacturing cell therapy products aligned with patient needs.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2021.11.003
Abstract: Chimeric Antigen Receptor T cell (CAR-T) therapies have demonstrated promising clinical response rates for patients with hematological malignancies. CAR-T cells are generated by bioengineering patient T cells to express CAR proteins that can specifically target… read more here.
Keywords: strategies manufacturing; manufacturing cell; cell therapy; cell ... See more keywords
On the Analysis of Effectiveness in a Manufacturing Cell: A Critical Implementation of Existing Approaches
Sign Up to like & getrecommendations! Published in 2017 at "Procedia Manufacturing"
DOI: 10.1016/j.promfg.2017.07.328
Abstract: Abstract OEE (Overall Equipment Effectiveness) is a widely used indicator in the evaluation of effectiveness of manufacturing systems. However, several authors published alternative approaches for its computation, complicating the implementation step for practitioners. This study… read more here.
Keywords: analysis effectiveness; cell critical; effectiveness manufacturing; critical implementation ... See more keywords