One Disease, Many Genes: Implications for the Treatment of Osteopetroses
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00085
Abstract: Osteopetrosis is a condition characterized by increased bone mass due to defects in osteoclast function or formation. In the last decades, the molecular dissection of osteopetrosis has unveiled a plethora of molecular players responsible for… read more here.
Keywords: many genes; implications treatment; disease many; one disease ... See more keywords
Complex Changes in the Efficiency of the Expression of Many Genes in Monogenic Diseases, Mucopolysaccharidoses, May Arise from Significant Disturbances in the Levels of Factors Involved in the Gene Expression Regulation Processes
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13040593
Abstract: Monogenic diseases are primarily caused by mutations in a single gene; thus, they are commonly recognized as genetic disorders with the simplest mechanisms. However, recent studies have indicated that the molecular mechanisms of monogenic diseases… read more here.
Keywords: many genes; expression; monogenic diseases; regulation ... See more keywords