Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
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DOI: 10.1002/cmdc.201900277
Abstract: A set of piperonylic acid derived hydrazones with variable isatin moieties was synthesized and evaluated for their inhibitory activity against the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidases A and B (MAO‐A/B). The results… read more here.
Keywords: derived hydrazones; acid derived; isatin moieties; piperonylic acid ... See more keywords
Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors
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DOI: 10.1002/cmdc.202000491
Abstract: Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors. The present work describes the syntheses of selected 1,3‐benzodioxine‐containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against… read more here.
Keywords: selected benzodioxine; acetylcholinesterase; containing chalcones; benzodioxine containing ... See more keywords
Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset
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DOI: 10.1007/s00210-020-01927-w
Abstract: Monoamine oxidase (MAO) type B (MAO-B) inhibition was shown to confer anti-parkinsonian benefit as monotherapy and adjunct to l-3,4-dihydroxyphenylalanine (l-DOPA) in clinical trials. Here, we explore the anti-parkinsonian effect of MAO type A (MAO-A) inhibition… read more here.
Keywords: mao; anti parkinsonian; monoamine oxidase; monotherapy ... See more keywords
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset
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DOI: 10.1007/s00210-020-01933-y
Abstract: Whereas monoamine oxidase (MAO) type B inhibitors are used as adjunct to L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD), the enzyme MAO type A (MAO-A) also participates in the metabolism of dopamine in… read more here.
Keywords: mptp lesioned; mao; moclobemide; dopa ... See more keywords
Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells
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DOI: 10.1007/s10534-017-0030-1
Abstract: Both monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson’s disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and… read more here.
Keywords: mao; monoamine oxidase; iron; activity ... See more keywords
The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
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DOI: 10.1007/s11030-020-10143-w
Abstract: Abstract Monoamine oxidase (MAO) is of much clinical relevance, and inhibitors of this enzyme are used in the treatment for neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease. The present study synthesises and… read more here.
Keywords: chromanone derivatives; tetralone chromanone; mao; monoamine oxidase ... See more keywords
A study of the phosphorylation proteomic skin characteristics of Tan sheep during the newborn and er-mao stages
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DOI: 10.1007/s11250-021-02899-6
Abstract: In this experiment, in order to study the formation mechanism of the lamb fur of Tan sheep, skin samples were collected from Tan sheep at the newborn and er-mao stages. Then, the phosphorylated proteomes of… read more here.
Keywords: tan sheep; skin samples; phosphorylation; mao ... See more keywords
Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment
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DOI: 10.1007/s12031-019-01366-0
Abstract: Inhibition of monoamine oxidase (MAO)-A/B can ameliorate depressive- and anxiety-related symptoms via increase of monoamine extracellular levels. However, such inhibition can also instigate hypertensive response following exposure to dietary tyramine (i.e., “the cheese effect”). Novel… read more here.
Keywords: cerebral mao; mao activity; treatment; inhibition ... See more keywords
Determination of dietary copper requirement by the monoamine oxidase activity in kidney of broilers from 1 to 21 days of age
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DOI: 10.1016/j.aninu.2021.05.013
Abstract: The current dietary copper (Cu) requirement (8 mg/kg) of broilers is mainly based on growth, hemoglobin concentration, or hematocrit, which might not be the most sensitive indices to evaluate dietary Cu requirements of broilers. The… read more here.
Keywords: age; oxidase; requirement; mao ... See more keywords
The micro-arc oxidation (MAO) behaviors of in-situ TiB2/A201 composite
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DOI: 10.1016/j.apsusc.2017.06.043
Abstract: Abstract The Micro-arc oxidation (MAO) treatment on the in-situ TiB2/A201 composites was performed using the aluminate-based electrolyte, and the corresponding MAO behavior was discussed in this work. In connection with the film thickness-time curve, the… read more here.
Keywords: micro arc; tib2 a201; mao; micro ... See more keywords
Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase‐A and ‐B
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DOI: 10.1016/j.bcp.2018.06.024
Abstract: Graphical abstract Figure. No caption available. &NA; The endocannabinoid system plays an important role in the pathophysiology of various neurological disorders, such as anxiety, depression, neurodegenerative diseases, and schizophrenia; however, little information is available on… read more here.
Keywords: virodhamine; inhibition mao; mao; monoamine oxidase ... See more keywords