One‐Step Hydrothermal Process to Fabricate Hydrophobic Mg–Al Layered Double Hydroxide Coating on MAO–Coated AZ31 Magnesium Alloy and Its Durability
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Engineering Materials"
DOI: 10.1002/adem.202402135
Abstract: In order to improve the corrosion resistance of micro‐arc oxidation (MAO) ceramic layer of AZ31 magnesium alloy, a hydrophobic Mg–Al layered double hydroxide (LDH) coating was prepared on its surface by a one‐step hydrothermal method.… read more here.
Keywords: step hydrothermal; hydrophobic; one step; coating ... See more keywords
Novel Purine‐Based Natural Products as Inhibitors of Cholinesterases and Monoamine Oxidases Presenting Potential Multitarget Therapeutics Tackling Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70035
Abstract: Alzheimer's disease (AD) is a complex neurological disorder that arises from multiple factors. The innovative multitarget‐directed ligand (MTDL) approach, which incorporates multiple pharmacophores into one molecule, enhances the development of effective therapeutics for AD. Eighteen… read more here.
Keywords: alzheimer disease; disease; multitarget; purine based ... See more keywords
Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900277
Abstract: A set of piperonylic acid derived hydrazones with variable isatin moieties was synthesized and evaluated for their inhibitory activity against the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidases A and B (MAO‐A/B). The results… read more here.
Keywords: derived hydrazones; acid derived; isatin moieties; piperonylic acid ... See more keywords
Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000491
Abstract: Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors. The present work describes the syntheses of selected 1,3‐benzodioxine‐containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against… read more here.
Keywords: selected benzodioxine; acetylcholinesterase; containing chalcones; benzodioxine containing ... See more keywords
KDS2010, a reversible MAO‐B inhibitor, extends the lifetime of neural probes by preventing glial scar formation
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24500
Abstract: Implantable neural probes have been extensively utilized in the fields of neurocircuitry, systems neuroscience, and brain‐computer interface. However, the long‐term functionality of these devices is hampered by the formation of glial scar and astrogliosis at… read more here.
Keywords: formation; glial scar; scar formation; mao ... See more keywords
Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01927-w
Abstract: Monoamine oxidase (MAO) type B (MAO-B) inhibition was shown to confer anti-parkinsonian benefit as monotherapy and adjunct to l-3,4-dihydroxyphenylalanine (l-DOPA) in clinical trials. Here, we explore the anti-parkinsonian effect of MAO type A (MAO-A) inhibition… read more here.
Keywords: mao; anti parkinsonian; monoamine oxidase; monotherapy ... See more keywords
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01933-y
Abstract: Whereas monoamine oxidase (MAO) type B inhibitors are used as adjunct to L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD), the enzyme MAO type A (MAO-A) also participates in the metabolism of dopamine in… read more here.
Keywords: mptp lesioned; mao; moclobemide; dopa ... See more keywords
Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0030-1
Abstract: Both monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson’s disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and… read more here.
Keywords: mao; monoamine oxidase; iron; activity ... See more keywords
The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10143-w
Abstract: Abstract Monoamine oxidase (MAO) is of much clinical relevance, and inhibitors of this enzyme are used in the treatment for neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease. The present study synthesises and… read more here.
Keywords: chromanone derivatives; tetralone chromanone; mao; monoamine oxidase ... See more keywords
A study of the phosphorylation proteomic skin characteristics of Tan sheep during the newborn and er-mao stages
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Animal Health and Production"
DOI: 10.1007/s11250-021-02899-6
Abstract: In this experiment, in order to study the formation mechanism of the lamb fur of Tan sheep, skin samples were collected from Tan sheep at the newborn and er-mao stages. Then, the phosphorylated proteomes of… read more here.
Keywords: tan sheep; skin samples; phosphorylation; mao ... See more keywords
Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01366-0
Abstract: Inhibition of monoamine oxidase (MAO)-A/B can ameliorate depressive- and anxiety-related symptoms via increase of monoamine extracellular levels. However, such inhibition can also instigate hypertensive response following exposure to dietary tyramine (i.e., “the cheese effect”). Novel… read more here.
Keywords: cerebral mao; mao activity; treatment; inhibition ... See more keywords