Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy
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DOI: 10.3390/ijms252312803
Abstract: Multi-target-directed ligands (MTDLs) represent a promising frontier in tackling the complexity of multifactorial pathologies like Alzheimer’s disease (AD). The synergistic inhibition of MAO-B, MAO-A, and AChE is believed to enhance treatment efficacy. A novel coumarin-based… read more here.
Keywords: kcal mol; mao ache; ache; mao ... See more keywords
Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors
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DOI: 10.3390/ph16010083
Abstract: Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, seventeen N-methyl-piperazine chalcones were synthesized, and their inhibitory activities were… read more here.
Keywords: piperazine chalcones; mao; methyl piperazine; ache ... See more keywords