The monoamine oxidase inhibition properties of C6-mono- and N3/C6-disubstituted derivatives of 4(3H)-quinazolinone.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.12.030
Abstract: Parkinson's disease is characterised by the death of the nigrostriatal neurons and depletion of striatal dopamine. The standard symptomatic therapy consists of dopamine replacement with l-dopa, the metabolic precursor of dopamine, which represents the most… read more here.
Keywords: mono disubstituted; disubstituted derivatives; derivatives quinazolinone; monoamine oxidase ... See more keywords
Structural exploration of multifunctional monoamine oxidase B inhibitors as potential drug candidates against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105070
Abstract: AD is one of the most typical neurodegenerative disorders that suffer many seniors worldwide. Recently, MAO inhibitors have received increasing attention not only for their roles involved in monoamine neurotransmitters metabolism and oxidative stress but… read more here.
Keywords: structural exploration; exploration multifunctional; monoamine oxidase; mao inhibitors ... See more keywords
Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114329
Abstract: The incorporation of the fluorine motif is a strategy widely applied in drug design for modulating the activity, physicochemical parameters, and metabolic stability of chemical compounds. In this study, we attempted to reduce the affinity… read more here.
Keywords: mao inhibitors; mao; fluorine atoms; affinity ... See more keywords
Development of Isopropyl-Tailed Chalcones as a New Class of Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disorder
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07694
Abstract: Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more effectively than MAO-A. Compound CA4 most potently inhibited MAO-B with an IC50 value of… read more here.
Keywords: mao; isopropyl; ca4; treatment parkinson ... See more keywords
Structural exploration of selected C6 and C7-substituted coumarin isomers as selective MAO-B inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2033643
Abstract: Abstract Monoamine Oxidase B is considered a successful target for developing antiparkinsonian drugs. Due to the side effects of current MAO-B inhibitors, there’s an urgent need for novel potent and highly selective MAO-B inhibitors. A… read more here.
Keywords: mao; substituted coumarin; mao inhibitors; coumarin isomers ... See more keywords
MAO inhibitors and their wider applications: a patent review
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1427735
Abstract: ABSTRACT Introduction: Monoamine oxidase (MAO) inhibitors, after the initial ‘golden age’, are currently used as third-line antidepressants (selective MAO-A inhibitors) or clinically enrolled as co-adjuvants for neurodegenerative diseases (selective MAO-B inhibitors). However, the research within… read more here.
Keywords: inhibitors wider; patent review; applications patent; mao ... See more keywords
An updated patent review on monoamine oxidase (MAO) inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2083501
Abstract: ABSTRACT Introduction Monoamine oxidase (MAO) inhibitors are currently used as antidepressants (selective MAO-A inhibitors) or as co-adjuvants for neurodegenerative diseases (selective MAO-B inhibitors). The research within this field is attracting attention due to their crucial… read more here.
Keywords: mao inhibitors; mao; oxidase mao; monoamine oxidase ... See more keywords
Time until Need for Levodopa among New Users of Dopamine Agonists or MAO-B Inhibitors
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DOI: 10.1155/2021/9952743
Abstract: Objective To investigate the use of dopamine agonists and monoamine oxidase type B (MAO-B) inhibitors in the Norwegian population, between 1 July 2006 and 31 December 2016. Our primary endpoint was time until need for… read more here.
Keywords: mao inhibitor; dopamine agonists; mao inhibitors; dopamine agonist ... See more keywords
Monoamineoxidase-B (MAO-B) Inhibitors in theTreatment of Alzheimer's and Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210203204710
Abstract: BACKGROUND The MAO enzyme which is presented in the brain and peripheral tissues and is a significant enzyme that is responsible for the deamination of biogenic amines and thus regulation of neurotransmitter levels. The reaction… read more here.
Keywords: treatment; mao inhibitors; mao; parkinson disease ... See more keywords
A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities.
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DOI: 10.2174/1389450117666151209123402
Abstract: The monoamine oxidase (MAO) enzyme is responsible for the deamination of monoamine neurotransmitters and regulates their concentration in the central and peripheral nervous systems. Imbalance in the concentration of neurotransmitters in the brain and central… read more here.
Keywords: mao; monoamine oxidase; drug; mao inhibitors ... See more keywords
Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.886408
Abstract: The monoamine oxidases (MAOs) are flavin-containing amine oxidoreductases responsible for metabolism of many biogenic amine molecules in the brain and peripheral tissues. Whereas serotonin is the preferred substrate of MAO-A, phenylethylamine is metabolized by MAO-B,… read more here.
Keywords: mao inhibitors; inhibition; tobacco ayahuasca; plant ... See more keywords