Stromal-derived MAOB promotes prostate cancer growth and progression
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adi4935
Abstract: Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), a mitochondrial enzyme that degrades biogenic and dietary… read more here.
Keywords: maob promotes; maob; growth progression; prostate cancer ... See more keywords
Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12020140
Abstract: Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells. Recently, we found that monoamine oxidase B (MAOB) catalyzed… read more here.
Keywords: hepatoma; maob; maob cells; endogenous gga ... See more keywords
The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurobiology"
DOI: 10.5607/en21007
Abstract: The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the proposal that reactive astrocytes… read more here.
Keywords: parkinsonian motor; genetic ablation; astrocytic maob; motor symptoms ... See more keywords