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   Articles with "map2k1" as a keyword



Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation.

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recommendations! Published in 2017 at "American journal of human genetics"

DOI: 10.1016/j.ajhg.2017.01.018

Abstract: Arteriovenous malformation (AVM) is a fast-flow, congenital vascular anomaly that may arise anywhere in the body. AVMs typically progress, causing destruction of surrounding tissue and, sometimes, cardiac overload. AVMs are difficult to control; they often… read more here.

Keywords: map2k1; map2k1 mutations; endothelial cells; arteriovenous malformation ... See more keywords

Cutaneous Rosai–Dorfman disease with MAP2K1 mutation, initially mimicking an infection with parasitized histiocytes

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recommendations! Published in 2024 at "Journal of Cutaneous Pathology"

DOI: 10.1111/cup.14700

Abstract: Rarely, Rosai–Dorfman disease (RDD) manifests exclusively in the skin, typically as nodules on the trunk and extremities. Recognition of characteristic histopathologic features enables diagnosis of RDD. A 55‐year‐old female presented with a 7‐year history of… read more here.

Keywords: parasitized histiocytes; map2k1 mutation; rosai dorfman; mutation ... See more keywords

High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer

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recommendations! Published in 2022 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-22-0302

Abstract: Abstract Activating mutations in mitogen-activated protein kinase kinase 1 (MAP2K1) are involved in a variety of cancers and may be classified according to their RAF dependence. Sensitivity to combined BRAF and MEK treatments is associated… read more here.

Keywords: map2k1 variants; evaluation; sensitivity; braf ... See more keywords

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.785526

Abstract: Background MAP2K1/2 genes are mutated in approximately 8% of melanoma patients; however, the impact of MAP2K1/2 gene alterations on the efficiency of immunotherapy has not been clarified. This study focused on the correlation between MAP2K1/2… read more here.

Keywords: map2k1; anti ctla; map2k1 mutations; treatment ... See more keywords