Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2017.01.018
Abstract: Arteriovenous malformation (AVM) is a fast-flow, congenital vascular anomaly that may arise anywhere in the body. AVMs typically progress, causing destruction of surrounding tissue and, sometimes, cardiac overload. AVMs are difficult to control; they often… read more here.
Keywords: map2k1; map2k1 mutations; endothelial cells; arteriovenous malformation ... See more keywords
Co-occurrence of targetable mutations in Non-small cell lung cancer (NSCLC) patients harboring MAP2K1 mutations.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.04.020
Abstract: BACKGROUND MAP2K1 mutations are rare in non-small cell lung cancer (NSCLC) and considered to be mutually exclusive from known driver mutations. Activation of the MEK1-cascade is considered pivotal in resistance to targeted therapy approaches, and… read more here.
Keywords: map2k1 mutations; nsclc patients; cell; lung cancer ... See more keywords
The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.785526
Abstract: Background MAP2K1/2 genes are mutated in approximately 8% of melanoma patients; however, the impact of MAP2K1/2 gene alterations on the efficiency of immunotherapy has not been clarified. This study focused on the correlation between MAP2K1/2… read more here.
Keywords: map2k1; anti ctla; map2k1 mutations; treatment ... See more keywords