TAK1/Map3k7 enhances differentiation of cardiogenic endoderm from mouse embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.10.002
Abstract: Specification of the primary heart field in mouse embryos requires signaling from the anterior visceral endoderm (AVE). The nature of these signals is not known. We hypothesized that the TGFβ-activated kinase (TAK1/Map3k7) may act as… read more here.
Keywords: cardiogenic endoderm; tak1 map3k7; map3k7; differentiation ... See more keywords
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111703119
Abstract: Significance Myelodysplastic syndromes (MDS) are the most commonly diagnosed malignancy of the elderly in the United States, but what causes severe anemia in MDS has been unknown. Our findings provide a detailed mechanism underlying the… read more here.
Keywords: differentiation; sf3b1 mutant; mds patients; map3k7 ... See more keywords
Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-1335
Abstract: The combined loss of CHD1 and MAP3K7 promotes aggressive prostate cancer by unknown mechanisms. Because both of these genes are lost genetically in prostate cancer, they cannot be directly targeted. We applied an established computational… read more here.
Keywords: map3k7; loss map3k7; prostate cancer; cancer ... See more keywords
MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0913
Abstract: Prostate cancer genomic subtypes that stratify aggressive disease and inform treatment decisions at the primary stage are currently limited. Previously, we functionally validated an aggressive subtype present in 15% of prostate cancer characterized by dual… read more here.
Keywords: map3k7; loss; cancer; chd1 ... See more keywords
Dependency of Spliceosomal Mutant MDS on Innate Immune Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-111552
Abstract: Mutations in genes encoding RNA splicing factors constitute the most common class of genetic alterations in patients with myelodysplastic syndromes (MDS). These occur as heterozygous point mutations at specific amino acid residues in SF3B1, SRSF2,… read more here.
Keywords: sf3b1; map3k7; figure; sf3b1 mutant ... See more keywords
Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189818
Abstract: In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. Here we report that overexpression of… read more here.
Keywords: sinoatrial node; map3k7; differentiation; overexpression map3k7 ... See more keywords