MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02007-w
Abstract: MAP4K4 is a Ste20 member and reported to play important roles in various pathologies, including in cancer. However, the mechanism by which MAP4K4 promotes pancreatic cancer is not fully understood. It is suggested that MAP4K4… read more here.
Keywords: map4k4; pancreatic cancer; map4k4 promotes; promotes pancreatic ... See more keywords
The membrane-localized protein kinase MAP4K4/TOT3 regulates thermomorphogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23112-0
Abstract: Plants respond to mild warm temperature conditions by increased elongation growth of organs to enhance cooling capacity, in a process called thermomorphogenesis. To this date, the regulation of thermomorphogenesis has been exclusively shown to intersect… read more here.
Keywords: tot3; map4k4; kinase; thermomorphogenesis ... See more keywords
In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2166039
Abstract: Abstract Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes.… read more here.
Keywords: f389 0746; selective map4k4; pancreatic cancer; map4k4 ... See more keywords
MBRS-39. MAP4K4 CONTROLS PRO-INVASIVE SIGNALING IN MEDULLOBLASTOMA CELLS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.550
Abstract: Abstract The molecular mechanisms contributing to distant dissemination and local recurrence of medulloblastoma, the most common malignant brain tumor in childhood, are poorly understood and no targeted anti-invasion therapies exist till date. We explored regulators… read more here.
Keywords: pro invasive; map4k4; medulloblastoma; growth factor ... See more keywords
The molecular basis of the dichotomous functionality of MAP4K4 in proliferation and cell motility control in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1059513
Abstract: The finely tuned integration of intra- and extracellular cues by components of the mitogen-activated protein kinase (MAPK) signaling pathways controls the mutually exclusive phenotypic manifestations of uncontrolled growth and tumor cell dissemination. The Ser/Thr kinase… read more here.
Keywords: cell; proliferation; kinase; map4k4 ... See more keywords
MAP4K4 and cancer: ready for the main stage?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1162835
Abstract: MAP4K4 is a serine/threonine kinase that belongs to the MAP kinase family and plays a critical role in embryogenesis and cellular migration. It contains approximately 1,200 amino acids and has a molecular mass of 140… read more here.
Keywords: map4k4 cancer; ready main; main stage; map4k4 ... See more keywords
Molecular Insights of MAP4K4 Signaling in Inflammatory and Malignant Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15082272
Abstract: Simple Summary The mitogen-activated protein kinase (MAPK) pathway plays a crucial role in inflammatory and malignant diseases. The MAPK signaling cascade is mediated by various members of the MAP4K, MAP3K, MAP2K, and MAPK families. One… read more here.
Keywords: role; kinase; inflammatory; map4k4 ... See more keywords
Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101786
Abstract: Background: Gastric cancer remains the most prevalent and highly lethal disease worldwide. MAP4K4, a member of Ste20, plays an important role in various pathologies, including cancer. However, its role in gastric cancer is not yet… read more here.
Keywords: high expression; map4k4; gastric cancer; tumor ... See more keywords