KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13213
Abstract: The kinase suppressor of rat sarcoma (RAS) proteins (KSR1 and KSR2) have long been considered as scaffolding proteins required for optimal mitogen‐activated protein kinase (MAPK) pathway signalling. However, recent evidence suggests that they play a… read more here.
Keywords: mapk pathway; mapk; cell proliferation;
Mutations involving TGFB and MAPK may be associated with malignancy in granular cell tumors
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.1002/gcc.23123
Abstract: Granular cell tumors (GrCTs) are mesenchymal neoplasms of presumed schwannian differentiation that may present as solitary or multifocal lesions with excision usually being curative. A minority of cases, however, show histological features associated with an… read more here.
Keywords: granular cell; associated malignancy; mutations involving; may associated ... See more keywords
Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF‐κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22597
Abstract: Ginsenoside Rh2 is a primary bioactive compound obtained from ginseng that indicated anticancer activities against several malignant tumors. However, previous studies have reported little about the inhibitory effect of Rh2 on osteosarcoma (OS). This study… read more here.
Keywords: u20s cells; rh2; pi3k akt; migration ... See more keywords
MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27451
Abstract: Unraveling molecular mechanisms that regulate tumor development and proliferation is of the utmost importance in the quest to decrease the high mortality rate of adrenocortical carcinomas (ACC). Our aim was to evaluate the role of… read more here.
Keywords: pathway inhibition; treatment; mapk; erk pathway ... See more keywords
Sclareol ameliorates hyperglycemia‐induced renal injury through inhibiting the MAPK/NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7465
Abstract: Diabetic nephropathy (DN) represents the most serious complication of diabetes. Previous studies have shown that the activation of nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK) are linked to inflammation in the development… read more here.
Keywords: signaling pathway; induced renal; mapk signaling; pathway sclareol ... See more keywords
Protective effect of wogonin on inflammatory responses in BisGMA‐treated macrophages through the inhibition of MAPK and NFκB pathways
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23655
Abstract: Composites, resins, and sealants that are commonly used in orthopedics and dentistry are based on 2,2‐bis[p‐(2′‐hydroxy‐3′‐methacryloxypropoxy)phenylene]propane (BisGMA), which induces proinflammatory responses in macrophages. The present study aimed to explore the anti‐inflammatory responses of wogonin, which… read more here.
Keywords: inflammatory responses; treated macrophages; bisgma treated; phosphorylation ... See more keywords
High-Throughput In Vitro Identification of Direct MAPK/Erk Substrates.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6424-6_9
Abstract: Phosphorylation mediated by cellular protein kinases is an effective mechanism employed by an organism to regulate central processes such as cell-cycle progression, metabolic pathways, cytoskeletal function, cell migration and differentiation. Thus, for example, various signaling… read more here.
Keywords: erk substrates; mapk erk; mapk; high throughput ... See more keywords
Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK
Sign Up to like & getrecommendations! Published in 2021 at "Virchows Archiv"
DOI: 10.1007/s00428-021-03119-0
Abstract: Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with… read more here.
Keywords: melanomas; melanomas mutated; clinicopathologic molecular; ctnnb1 mapk ... See more keywords
Parkia speciosa empty pod extract exerts anti-inflammatory properties by modulating NFκB and MAPK pathways in cardiomyocytes exposed to tumor necrosis factor-α
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0267-8
Abstract: Parkia speciosa Hassk is a plant found abundantly in the Southeast Asia region. Its seeds, with or without pods, have been used in traditional medicine locally to treat cardiovascular problems. The pathogenesis of cardiovascular diseases… read more here.
Keywords: pse; tnf; parkia speciosa; factor ... See more keywords
Effect of l-carnitine on cardiotoxicity and apoptosis induced by imatinib through PDGF/ PPARγ /MAPK pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108866
Abstract: A tyrosine kinase inhibitor Imatinib (IM) is used in the treatment of different varieties of cancers. The current study was designed to explore the beneficial role of l-carnitine against IM-induced cardiotoxicity in rats. Male albino… read more here.
Keywords: ppar; mapk pathways; ppar mapk; pdgf ppar ... See more keywords
Microcystin-LR influences the in vitro oocyte maturation of zebrafish by activating the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2019.105261
Abstract: Harmful cyanobacteria and their production of microcystins (MCs) exert significant toxicity on reproduction of fish, especially the process of oogenesis. Our previous studies demonstrated that MCs have negative impacts on the quantity and quality of… read more here.
Keywords: oocyte maturation; maturation; influences vitro; microcystin influences ... See more keywords