Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10117-3
Abstract: To identify possible genetic variants influencing expression of EPHA2 (Ephrin-receptor Type-A2), a tyrosine kinase receptor that has been shown to be important for lens development and to contribute to both congenital and age related cataract… read more here.
Keywords: pax2 binding; binding site; mapk akt; epha2 promoter ... See more keywords
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2020.1801777
Abstract: Abstract Cervical cancer (CC) is a common gynecological malignancy and represents a major global health challenge. Chemotherapeutic agents are commonly applied in treatment of CC, while along various adverse effects and chemotherapy resistance. As an… read more here.
Keywords: mapk akt; cervical cancer; cell growth; migration ... See more keywords
P38 MAPK/AKT signalling is involved in IL-33-mediated anti-apoptosis in childhood acute lymphoblastic leukaemia blast cells
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Medicine"
DOI: 10.1080/07853890.2021.1970217
Abstract: Abstract Background Acute lymphoblastic leukaemia (ALL) is often characterized by broad clinical and biological heterogeneity, as well as recurrent genetic aberrations. Despite remarkable improvements in the treatment outcome in paediatric ALL over the past several… read more here.
Keywords: p38 mapk; apoptosis; mapk akt; acute lymphoblastic ... See more keywords
AQP4‑knockout alleviates the lipopolysaccharide‑induced inflammatory response in astrocytes via SPHK1/MAPK/AKT signaling.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2018.3749
Abstract: To date, aquaporin‑4 (AQP4) has been considered as a critical contributor to neuroinflammation, but little is known about the underlying mechanism. Previous studies have shown that a critical enzyme involved in the sphingomyelin cycle, sphingosine kinase 1 (SPHK1),… read more here.
Keywords: akt signaling; sphk1; mapk akt; aqp4 ... See more keywords
Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13582
Abstract: Heat shock protein (HSP) 20 belongs to the small HSP family and exhibits diverse functions, including tumor suppression, in addition to being a molecular chaperon, which is the classical property of HSPs. The present study… read more here.
Keywords: shock protein; heat shock; hsp20; akt signaling ... See more keywords