Abstract B035: Targeting transcriptional elongation kinases prevents adaptation to KRASG12C inhibitors in both MAPK-dependent and -independent models of acquired resistance
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DOI: 10.1158/1557-3125.ras23-b035
Abstract: The development of covalent inhibitors targeting KRASG12C mutations offers a precision medicine approach to a large cohort of lung cancer patients previously lacking opportunities for targeted therapy. Despite promising initial responses ranging from disease control… read more here.
Keywords: acquired resistance; mapk dependent; krasg12c inhibitors; krasg12c ... See more keywords
p38 MAPK‐dependent phosphorylation of TFEB promotes monocyte‐to‐macrophage differentiation
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DOI: 10.15252/embr.202255472
Abstract: The transcription factor EB (TFEB) regulates energy homeostasis and cellular response to a wide variety of stress conditions, including nutrient deprivation, oxidative stress, organelle damage, and pathogens. Here we identify S401 as a novel phosphorylation… read more here.
Keywords: tfeb; mapk dependent; dependent phosphorylation; p38 mapk ... See more keywords
The Binding of CSL Proteins to Either Co-Activators or Co-Repressors Protects from Proteasomal Degradation Induced by MAPK-Dependent Phosphorylation
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DOI: 10.3390/ijms232012336
Abstract: The primary role of Notch is to specify cellular identities, whereby the cells respond to amazingly small changes in Notch signalling activity. Hence, dosage of Notch components is crucial to regulation. Central to Notch signal… read more here.
Keywords: mapk dependent; dependent phosphorylation; csl proteins; csl ... See more keywords