BRAF molecular testing in cytopathology: Implications for diagnosis, prognosis, and targeted therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22209
Abstract: The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that transduces signals from the cell membrane through the mitogen-activated protein kinase (MAPK) phosphorylation cascade to promote global cellular responses including growth, proliferation, survival,… read more here.
Keywords: molecular testing; braf; cytopathology; braf molecular ... See more keywords
Vascular endothelial growth factor promotes transdifferentiation of astrocytes into neurons via activation of the MAPK/Erk‐Pax6 signal pathway
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24361
Abstract: Reactive astrocytes can be transformed into new neurons. Vascular endothelial growth factor (VEGF) promotes the transformation of reactive astrocytes into neurons in ischemic brain. Therefore, in this study, the molecular mechanism of VEGF's effect on… read more here.
Keywords: vegf enhanced; vegf; mapk erk; astrocytes neurons ... See more keywords
Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30818
Abstract: Cancer cells undergo metabolic adaptation to sustain uncontrolled proliferation. Aerobic glycolysis and glutaminolysis are two of the most essential characteristics of cancer metabolic reprogramming. Hyper-activated PI3K/Akt and MAPK/ERK signaling pathways play central roles in cancer… read more here.
Keywords: erk; pi3k akt; metabolic adaptation; akt mapk ... See more keywords
MicroRNA‐23a inhibits melanoma cell proliferation, migration, and invasion in mice through a negative feedback regulation of sdcbp and the MAPK/ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.1979
Abstract: Melanoma is the main cause of death associated with skin cancer. Surgical resection and adjuvant therapy are currently effective treatments, but the recurrence rate is very high. The understanding of microRNA (miR) dynamics after surgical… read more here.
Keywords: sdcbp; sdcbp mapk; signaling pathway; erk signaling ... See more keywords
MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27451
Abstract: Unraveling molecular mechanisms that regulate tumor development and proliferation is of the utmost importance in the quest to decrease the high mortality rate of adrenocortical carcinomas (ACC). Our aim was to evaluate the role of… read more here.
Keywords: pathway inhibition; treatment; mapk; erk pathway ... See more keywords
High-Throughput In Vitro Identification of Direct MAPK/Erk Substrates.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6424-6_9
Abstract: Phosphorylation mediated by cellular protein kinases is an effective mechanism employed by an organism to regulate central processes such as cell-cycle progression, metabolic pathways, cytoskeletal function, cell migration and differentiation. Thus, for example, various signaling… read more here.
Keywords: erk substrates; mapk erk; mapk; high throughput ... See more keywords
Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03798-4
Abstract: It is of great significance to explore the molecular mechanism of thyroid cancer (TC) pathogenesis for its improvement and therapy. Growth factor receptor bound protein-7 (GRB7) has been regarded as an important regulatory gene in… read more here.
Keywords: protein; mitochondrial apoptosis; cell cycle; proliferation ... See more keywords
Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.052
Abstract: Glioma is one of the most common primary brain tumors in adults with a high mortality rate and relapse rate. Thus, finding better effective approaches to treat glioma has become very urgent. Astragaloside IV (AS-IV),… read more here.
Keywords: glioma; signaling pathway; erk signaling; astragaloside inhibits ... See more keywords
Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.143
Abstract: We explored the ability of a long non-coding RNA H19, to influence oxidative stress (OS) and chemotherapy resistance of CD133 + cancer stem cells via the MAPK/ERK signaling pathway in HCC. HCC tissues with corresponding adjacent normal… read more here.
Keywords: chemotherapy resistance; mapk; expression; cell ... See more keywords
Benzophenone-3 induced abnormal development of enteric nervous system in zebrafish through MAPK/ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.130670
Abstract: Hirschsprung disease (HSCR) is a congenital disease characterized by the absence of enteric neurons, which is derived from the failure of the proliferation, differentiation or migration of the enteric neural crest cells (ENCCs). HSCR is… read more here.
Keywords: mapk erk; development enteric; nervous system; enteric nervous ... See more keywords
ASSOCIATION OF MAPK/ERK PATHWAY ACTIVATION WITH KRAS MUTATIONS IN ADENOMATOID ODONTOGENIC TUMORS
Sign Up to like & getrecommendations! Published in 2019 at "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"
DOI: 10.1016/j.oooo.2019.02.034
Abstract: Objectives Adenomatoid odontogenic tumors (AOT) are benign tumors derived from odontogenic epithelium, and they account for 2-7% of all odontogenic tumors. Intraosseous AOTs are thought to be associated with unerupted permanent teeth, although their pathogenesis… read more here.
Keywords: mutation; association; odontogenic tumors; adenomatoid odontogenic ... See more keywords