MAPK inhibition augments the T-cell response against HOXB7-expressing tumor through HLA upregulation.
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DOI: 10.1111/cas.15619
Abstract: Homeobox B7 (HOXB7) is a master regulatory gene that regulates cell proliferation and activates oncogenic pathways. Overexpression of HOXB7 correlates with aggressive behavior and poor prognosis in patients with cancer. However, the expression and role… read more here.
Keywords: cancer; hoxb7; tumor; mapk inhibition ... See more keywords
ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK Inhibition
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DOI: 10.1158/1078-0432.ccr-19-1359
Abstract: Purpose: Enhanced lipogenesis and mitochondrial function are two critical metabolic characteristics in melanoma, but their crosstalk involved in tumor biology and targeted therapy remains unknown. ATP-citrate lyase (ACLY) is a crucial lipogenic enzyme that is… read more here.
Keywords: biology; melanoma growth; melanoma; inhibition ... See more keywords
Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study
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DOI: 10.1158/1078-0432.ccr-22-0437
Abstract: Abstract Purpose: Restoration of iodine incorporation (redifferentiation) by MAPK inhibition was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma (RR-TC). However, results were unsatisfactory in BRAFV600E-mutant (BRAF-MUT) RR-TC. Here we assess safety and efficacy of redifferentiation… read more here.
Keywords: arm; redifferentiation; braf; radioiodine refractory ... See more keywords
Abstract 3893: KRAS G12C colon cancer resistance to vertical MAPK inhibition converges on FOS-JUN signaling through orthogonal mechanisms
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DOI: 10.1158/1538-7445.am2023-3893
Abstract: KRAS G12C mutations in cancer can be targeted by G12C-specific inhibitors, but resistance develops rapidly. Preclinical studies suggested multiple drug combinations to improve efficacy, including CDK4/6, MEK, ERK, EGFR, and SHP2 inhibitors, collectively called vertical… read more here.
Keywords: kras g12c; cancer; vertical mapk; resistance ... See more keywords
Linking MAPK inhibition and the response to TNF in melanoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24143
Abstract: e24143Background: Antigen presentation plays a central role in anti-tumor immunity and the response to immunotherapy. Recent studies have underscored the importance of MHC class I (MHC I) and class... read more here.
Keywords: response; linking mapk; mapk inhibition; inhibition response ... See more keywords