Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01582
Abstract: Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relationship-driven expansion… read more here.
Keywords: interacting kinases; fragment hits; stepwise evolution; evolution fragment ... See more keywords
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015568
Abstract: The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to cellular responses by regulating mRNA translation and mRNA translation influences platelet production and… read more here.
Keywords: mnk1 regulates; mnk1; interacting kinase; mapk interacting ... See more keywords