KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13213
Abstract: The kinase suppressor of rat sarcoma (RAS) proteins (KSR1 and KSR2) have long been considered as scaffolding proteins required for optimal mitogen‐activated protein kinase (MAPK) pathway signalling. However, recent evidence suggests that they play a… read more here.
Keywords: mapk pathway; mapk; cell proliferation;
Mechanism of thymosin β4 in ameliorating liver fibrosis via the MAPK/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23338
Abstract: Liver fibrosis is a grievous global challenge, where hepatic stellate cells (HSCs) activation is a paramount step. This study analyzed the mechanism of Tβ4 in ameliorating liver fibrosis via the MAPK/NF-κB pathway. The liver fibrosis… read more here.
Keywords: mapk pathway; fibrosis; liver fibrosis; activation ... See more keywords
PP‐22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE‐2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27076
Abstract: Paris polyphylla var. yunnanensis, named Chong Lou, is considered an antitumor substance. In this study, we investigated the effect of PP‐22, a monomer purified from P. polyphylla var. yunnanensis, on the nasopharyngeal carcinoma cell line… read more here.
Keywords: cell line; apoptosis; cne; mapk pathway ... See more keywords
Overexpression of long noncoding RNA SLC26A4‐AS1 inhibits the epithelial–mesenchymal transition via the MAPK pathway in papillary thyroid carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29145
Abstract: Papillary thyroid carcinoma (PTC) is recognized as one of the most prevalent types of thyroid cancer with poor prognosis. Long noncoding RNA (lncRNA) has undergone an intensive study for their involvement in tumor treatment. This… read more here.
Keywords: ptc; slc26a4 as1; as1; mapk pathway ... See more keywords
LncRNA MEG3 ameliorates NiO nanoparticles‐induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23464
Abstract: The lung inflammatory damage could result from the nickel oxide nanoparticles (NiO NPs), in which the underlying mechanism is still unclear. This article explored the roles of long noncoding RNA maternally expressed gene 3 (lncRNA… read more here.
Keywords: inflammatory damage; nio nps; lncrna meg3; mapk pathway ... See more keywords
Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1837-8
Abstract: Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors… read more here.
Keywords: astrocytoma piloid; mapk pathway; anaplastic astrocytoma; idh wildtype ... See more keywords
First insights for targeted therapies in odontogenic myxoma
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-03107-4
Abstract: Objective Odontogenic myxoma (OM) occasionally responds poorly to surgical treatment. The MAPK pathway is constitutively activated in several neoplasms and we aimed to test if the MAPK pathway is activated in OM, in order to… read more here.
Keywords: odontogenic myxoma; insights targeted; mapk pathway; targeted therapies ... See more keywords
Human amniotic membrane mesenchymal stem cells exert cardioprotective effects against isoproterenol (ISO)-induced myocardial injury through suppression of inflammation and modulation of inflammatory MAPK/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue banking"
DOI: 10.1007/s10561-021-09915-x
Abstract: A common cause of mortality around the world is ischemic myocardial injury. The study was conducted to examine the ability of amniotic membrane mesenchymal stem cells (AMSCs) for protection against isoproterenol (ISO)-induced myocardial injury and… read more here.
Keywords: inflammatory mapk; inflammation; myocardial injury; mapk pathway ... See more keywords
Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-020-09578-6
Abstract: Osteoclasts are crucial cellular components of bone and are the cause of various bone problems like osteoporosis. Various biological activities such as anti-tumorous, anti-inflammatory, antibacterial, and immunomodulatory function are influenced by Sclareol, as a natural… read more here.
Keywords: sclareol; mapk pathway; rankl induced; bone ... See more keywords
DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01455-7
Abstract: Purpose Papillary thyroid carcinoma (PTC) is characterized by epithelial malignancy and is the most prevalent thyroid neoplasm with the best overall prognosis. Notably, recently published studies have indicated remarkably high expression of dipeptidyl peptidase 4 (DPP4)… read more here.
Keywords: dpp4; mapk pathway; expression; ptc ... See more keywords
5-Fluorouracil enhances the chemosensitivity of gastric cancer to TRAIL via inhibition of the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.006
Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cancer cells are usually insensitive to TRAIL so… read more here.
Keywords: apoptosis; trail; gastric cancer; mapk pathway ... See more keywords