MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22619
Abstract: Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The… read more here.
Keywords: dusp1; therapeutic targets; gene expression; mapk pathways ... See more keywords
Polyene Phosphatidylcholine Interacting with TLR-2 Prevents the Synovial Inflammation via Inactivation of MAPK and NF-κB Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammation"
DOI: 10.1007/s10753-022-01633-0
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune joint disease that causes cartilage and bone damage or even disability, seriously endangering human health. Chronic synovial inflammation has been shown to play a vital role in disease… read more here.
Keywords: polyene phosphatidylcholine; synovial inflammation; inflammation; ppc ... See more keywords
Stress Responses Against Rare Earth Ions Are Mediated by the JNK and p38 MAPK Pathways in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1577-6
Abstract: Rare earth (RE) ions at high concentrations are toxic to many organisms as they induce oxidative stress and cause improper incorporation of the ions into calcium-binding proteins. Although the mechanism of action underlying the toxicity… read more here.
Keywords: rare earth; caenorhabditis elegans; jnk p38; mapk pathways ... See more keywords
Inhibition of miR-217 Protects Against Myocardial Ischemia–Reperfusion Injury Through Inactivating NF-κB and MAPK Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Engineering and Technology"
DOI: 10.1007/s13239-019-00452-z
Abstract: Purpose Recent studies have demonstrated that miRNAs play a vital role in regulating myocardial ischemia/reperfusion injury (MIRI). MiR-217 has been proven to be implicated in cardiac diseases such as chronic heart failure and cardiac myxoma.… read more here.
Keywords: inactivating mapk; inhibition; myocardial ischemia; mapk pathways ... See more keywords
Effect of l-carnitine on cardiotoxicity and apoptosis induced by imatinib through PDGF/ PPARγ /MAPK pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108866
Abstract: A tyrosine kinase inhibitor Imatinib (IM) is used in the treatment of different varieties of cancers. The current study was designed to explore the beneficial role of l-carnitine against IM-induced cardiotoxicity in rats. Male albino… read more here.
Keywords: ppar; mapk pathways; ppar mapk; pdgf ppar ... See more keywords
Lactoferrin Relieves Deoxynivalenol-Induced Oxidative Stress and Inflammatory Response by Modulating the Nrf2/MAPK Pathways in the Liver.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01035
Abstract: Deoxynivalenol (DON), one of the most common mycotoxins contaminating food and feed, has been shown to induce hepatotoxicity. Lactoferrin (LF) enriched in human milk is a critical functional food component and performs the hepatoprotection function.… read more here.
Keywords: inflammatory response; mapk pathways; oxidative stress; hepatotoxicity ... See more keywords
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0335-z
Abstract: The molecular signature underlying autism spectrum disorder remains largely unknown. This study identifies differential expression of mTOR and MAPK pathways in patients affected by mild and severe idiopathic autism. A total of 55 subjects were… read more here.
Keywords: autism; mapk pathways; mtor mapk; severity ... See more keywords
CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2017.1300681
Abstract: Abstract Objective: As the alternate receptor for stromal cell-derived factor-1 (SDF-1) except CXCR4, CXCR7 has been shown to be involved in the progression of some malignancies. However, the role of SDF-1/CXCR7 in gastric cancer (GC)… read more here.
Keywords: gastric cancer; mapk pathways; progression; sdf ... See more keywords
AB0072 Rational designed gold nanoparticle suppresses rankl-induced osteoclastogenesis in raw264.7 cells via NF-KAPPA B pathway and MAPK pathways
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2087
Abstract: Background Bone erosion in joint is the most deleterious effect induced by rheumatoid arthritis (RA) and is the major cause of disability. New therapies are urgently required to prevent RA-associated bone destruction. The excessive bone… read more here.
Keywords: raw264; rankl; mapk pathways; rational designed ... See more keywords
Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-γ-Mediated Suppression of the NF-κB and MAPK Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2030818
Abstract: Physical exercise is recommended as a preventative approach for osteoporosis; however, the effect of physical exercise on bone mass remains controversial. Additionally, the immune regulation of physical exercise on bone mass remains unclear. To determine… read more here.
Keywords: ovx mice; bone; mapk pathways; ifn ... See more keywords
Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF-κB and MAPK Pathways in LPS-Stimulated BV-2 Microglia
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/3263446
Abstract: Baicalin (BA) is a major flavone from Scutellaria baicalensis Georgi and has showed significant curative effects in Parkinson's and Alzheimer's diseases. In the present study, we investigated the effects of BA on antineuroinflammation and related… read more here.
Keywords: baicalin; lps stimulated; mapk pathways; myd88 mapk ... See more keywords