Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK–PI3K/AKT signaling
Sign Up to like & getrecommendations! Published in 2020 at "Medical Oncology"
DOI: 10.1007/s12032-020-01391-9
Abstract: Salicylidene acylhydrazide group synthetic compounds ME0053, ME005 and ME0192 are known for their iron chelating properties and due to these properties they are primarily used for blocking the bacterial type 3 secretory virulence system. On… read more here.
Keywords: speedy ringo; erk mapk; mapk pi3k; pi3k akt ... See more keywords
Streptococcus pneumoniae aminopeptidase N contributes to bacterial virulence and elicits a strong innate immune response through MAPK and PI3K/AKT signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Microbiology"
DOI: 10.1007/s12275-020-9538-0
Abstract: Streptococcus pneumoniae is a Gram-positive pathogen with high morbidity and mortality globally but some of its pathogenesis remains unknown. Previous research has provided evidence that aminopeptidase N (PepN) is most likely a virulence factor of… read more here.
Keywords: mapk pi3k; akt signaling; virulence; pneumoniae ... See more keywords
Papain exerts an anti-atherosclerosis effect with suppressed MPA-mediated foam cell formation by regulating the MAPK and PI3K/Akt-NF-κB pathways
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2023.2194531
Abstract: ABSTRACT Background Papain possesses a potential anti-atherosclerosis (AS) effect. This study aimed to explore the inhibitory effects of papain on the monocyte-platelet aggregates (MPAs)-mediated production of foam cells in vitro and AS in vivo. Research… read more here.
Keywords: mapk pi3k; pi3k akt; foam cell; akt pathways ... See more keywords
Quadruple‐editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS‐mutated colorectal cancer cells
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DOI: 10.1111/cas.15049
Abstract: Mutated KRAS promotes the activation of the MAPK pathway and the progression of colorectal cancer (CRC) cells. Aberrant activation of the PI3K pathway strongly attenuates the efficacy of MAPK suppression in KRAS‐mutated CRC. The development… read more here.
Keywords: kras mutated; crc cells; quadruple editing; mapk pi3k ... See more keywords
Abstract 4043: Stimulation of the mapk and pi3k/akt pathways in pancreatic cancer cells by polyisoprenylated cysteinyl amide inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4043
Abstract: Pancreatic cancer is the third deadliest cancer with a 5-year survival rate of less than 10%. Over 90% of reported cases are driven by KRAS mutations. KRAS signals through the MAPK and PI3K pathways. Targeting… read more here.
Keywords: mapk pi3k; pancreatic cancer; nsl yhj; polyisoprenylated cysteinyl ... See more keywords
Abstract PR04: Small molecule-mediated activation of Ras elicits inhibition of MAPK and PI3K signaling though pathway feedback
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-pr04
Abstract: Oncogenic mutation or hyper-activation of Ras results in aberrant cellular signaling and is responsible for approximately 30% of all human tumors. Therefore, Ras is an outstanding candidate for therapeutic inhibition. However, the discovery of potent… read more here.
Keywords: pi3k; mapk pi3k; inhibition; activation ras ... See more keywords
Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01469
Abstract: Lung cancer is the most prevalent in cancer-related deaths, while breast carcinoma is the second most dominant cancer in women, accounting for the most number of deaths worldwide. Cancers are heterogeneous diseases that consist of… read more here.
Keywords: cancer; mapk pi3k; akt mtor; pi3k akt ... See more keywords
Alpinumisoflavone Impairs Mitochondrial Respiration via Oxidative Stress and MAPK/PI3K Regulation in Hepatocellular Carcinoma Cells
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DOI: 10.3390/antiox11101929
Abstract: Alpinumisoflavone is a natural prenylated isoflavonoid extracted from the raw fruit of Cudrania tricuspidata. Several studies have reported the beneficial characteristics of alpinumisoflavone, such as its antioxidant, anti-inflammation, anti-bacterial, osteoprotective, and neuroprotective effects. Alpinumisoflavone also… read more here.
Keywords: cancer; mitochondrial respiration; hepatocellular carcinoma; mapk pi3k ... See more keywords
The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K–Akt Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030590
Abstract: The targeting of the Mitogen-Activated Protein Kinase (MAPK) signalling pathway in melanoma improves the prognosis of patients harbouring the V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) mutation. However, a fraction of these patients may… read more here.
Keywords: pi3k; pi3k akt; mapk pi3k; melanoma ... See more keywords