Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13046
Abstract: RAS-MAPK signaling promotes immune evasion and cancer cell survival, and MAPK inhibitors (MAPKi) are frequently used as cancer therapies. Despite progress elucidating the direct effects of MAPKi on immune cells, their indirect effect on the… read more here.
Keywords: treatment; mapki; cd73; mapk signaling ... See more keywords
Antioxidant Cascade Nanoenzyme Antagonize Inflammatory Pain by Modulating MAPK/p‐65 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206934
Abstract: Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low‐addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti‐oxidative stress and anti‐inflammatory properties… read more here.
Keywords: signaling pathway; mapk signaling; sfz nps; cascade nanoenzyme ... See more keywords
New insights into arsenic, lead, and iron neurotoxicity: Activation of MAPK signaling pathway and oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23040
Abstract: Toxic metals cause neurodegeneration via formation of toxic complexes with the cellular compounds and production of highly reactive oxygen species. The present study aimed to investigate the role of mitogen-activated protein kinase (MAPK) signaling pathway… read more here.
Keywords: mapk signaling; iron; lead; signaling pathway ... See more keywords
Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF‐KB and MAPK signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26575
Abstract: Osteoporosis is a major debilitating cause of fractures and decreases the quality of life in elderly patients. Bone homeostasis is maintained by bone forming osteoblasts and bone resorpting osteoclasts. Substantial evidences have shown that targeting… read more here.
Keywords: induced osteoclastogenesis; rankl induced; mapk signaling; osteolysis ... See more keywords
Aspergillus cristatum attenuates DSS-induced intestinal barrier damage through reducing the oxidative stress, regulating short-chain fatty acid and inhibiting MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12334
Abstract: BACKGROUND Probiotic are regarded as a promising strategy for relieving colitis caused by DSS. One of dominant probiotic fungi in Fuzhuan brick tea is identified as Aspergillus cristatum, but whether it can effectively improve colitis… read more here.
Keywords: cristatum; dss induced; mapk signaling; barrier damage ... See more keywords
Sclareol ameliorates hyperglycemia‐induced renal injury through inhibiting the MAPK/NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7465
Abstract: Diabetic nephropathy (DN) represents the most serious complication of diabetes. Previous studies have shown that the activation of nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK) are linked to inflammation in the development… read more here.
Keywords: signaling pathway; induced renal; mapk signaling; pathway sclareol ... See more keywords
The toxicity of cooking oil fumes on human bronchial epithelial cells through ROS‐mediated MAPK, NF‐κB signaling pathways and NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23465
Abstract: Cooking oil fumes (COFs) are the main pollutants in kitchen and indoor air, which threaten human health. Exposure to COFs may lead to respiratory diseases and impair pulmonary function. To investigate the toxicity of COFs… read more here.
Keywords: mapk signaling; cooking oil; toxicity; human bronchial ... See more keywords
Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-021-01192-1
Abstract: Stress granule (SG) assembly is a conserved cellular strategy that copes with stress-related damage and promotes cell survival. SGs form through a process of liquid-liquid phase separation. Cellular signaling also appears to employ SG assembly… read more here.
Keywords: granules safeguard; stress granules; hyperactivation; mapk signaling ... See more keywords
MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2745-y
Abstract: PurposeMicroRNAs (miRs) play an important role in many cancers and can affect cancer cell behavior, including glioma. This study aims at investigating the effects of miR-338-5p on the senescence, migration, invasion, and apoptosis of glioma… read more here.
Keywords: glioma; signaling pathway; mapk signaling; expression ... See more keywords
Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-κB and p38/MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-019-01016-w
Abstract: Several cellular and molecular processes participate in the pathologic changes of osteoarthritis (OA). However, the core molecular regulators of these processes are unclear, and no effective treatment for OA disease has been developed so far.… read more here.
Keywords: p38 mapk; upregulation promotes; mapk signaling; human chondrocytes ... See more keywords
The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04772-0
Abstract: To study the role of MAPK signaling pathway in the development of Epithelial-mesenchymal transition in oral squamous cell carcinoma induced by inflammatory factor TNF-α. After the action of TNF-α, the expression of JNK, ERK, P38… read more here.
Keywords: carcinoma; oral squamous; signaling pathway; mapk signaling ... See more keywords