Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03278-1
Abstract: Intervertebral disc degeneration (IDD) is accompanied by nucleus pulposus (NP) cell apoptosis, inflammation, and extracellular matrix degradation. Tumour necrosis factor receptor 1 (TNFR1) is a receptor of TNF-α, and is deeply involved in the processes… read more here.
Keywords: tnfr1; mapk signalling; apoptosis inflammation;
Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules
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DOI: 10.1038/s41598-017-04913-0
Abstract: The mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade is a vital component of plant cellular signalling. Despite this, MAPK signalling cascade is less characterized in crop legumes. To fill this void, we present here a comprehensive… read more here.
Keywords: mkks mapks; chickpea; analysis; mapk signalling ... See more keywords
Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling
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DOI: 10.1080/13880209.2019.1657906
Abstract: Abstract Context: Oxymatrine (OMT) has various pharmacological effects, including immune reaction regulation, anti-inflammation and anti-hypersensitive reaction. Objective: This is the first report to investigate the molecular mechanism of OMT function in l-arginine (Arg)-induced acute pancreatitis… read more here.
Keywords: acute pancreatitis; arg; arg induced; mapk signalling ... See more keywords
FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2039216
Abstract: Abstract Context Ferulic acid ethyl ester (FAEE) is abundant in Ligusticum chuanxiong Hort. (Apiaceae) and grains, and possesses diverse biological activities; but the effects of FAEE on osteoporosis has not been reported. Objective This study… read more here.
Keywords: faee exerts; signalling pathway; mapk signalling; osteoporosis ... See more keywords
Galangin suppresses RANKL‐induced osteoclastogenesis via inhibiting MAPK and NF‐κB signalling pathways
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DOI: 10.1111/jcmm.16430
Abstract: Osteoclasts play a critical role in osteoporosis; thus, inhibiting osteoclastogenesis is a therapeutic strategy for osteoporosis. Galangin, a natural bioflavonoid extracted from a traditional Chinese herb, possesses a variety of biological activities, including anti‐inflammation and… read more here.
Keywords: treatment; signalling pathways; mapk signalling; galangin ... See more keywords
Astragalus polysaccharide attenuates LPS‐related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16683
Abstract: Bacterial products can stimulate inflammatory reaction and activate immune cells to enhance the production of inflammatory cytokines, and finally promote osteoclasts recruitment and activity, leading to bone destruction. Unfortunately, effective preventive and treatment measures for… read more here.
Keywords: lps related; mapk signalling; inflammatory osteolysis; osteolysis ... See more keywords
Role of p38 MAPK Signalling in Testis Development and Male Fertility
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DOI: 10.1155/2022/6891897
Abstract: The testis is an important male reproductive organ, which ensures reproductive function via the secretion of testosterone and the generation of spermatozoa. Testis development begins in the embryonic period, continues after birth, and generally reaches… read more here.
Keywords: testis; mapk signalling; p38 mapk; testis development ... See more keywords
Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis
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DOI: 10.1186/s12987-021-00288-7
Abstract: Background The Gram-negative bacterium Neisseria meningitidis ( Nm ) can cause meningitis in humans, but the host signalling pathways manipulated by Nm during central nervous system (CNS) entry are not completely understood. Methods We investigate… read more here.
Keywords: response; infection; neisseria meningitidis; choroid plexus ... See more keywords
The effect of photomodulation on fibroblast growth factor and the Ras/MAPK signalling pathway: a review.
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DOI: 10.12968/jowc.2022.31.10.832
Abstract: OBJECTIVE Current therapies and technologies used to treat hard-to-heal diabetic wounds are limited to a 50% healing rate. The rise in the percentage of lower limb non-traumatic amputations in patients with diabetes has caused an… read more here.
Keywords: ras mapk; mapk signalling; growth factor; signalling pathway ... See more keywords
Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production
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DOI: 10.3390/ijms20061346
Abstract: There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling that are involved in neuronal development, cellular differentiation, cell migration, cancer, cardiovascular dysfunction and inflammation via their functions in promoting apoptosis and cell motility… read more here.
Keywords: p38 mapk; cyclic amp; system; mapk signalling ... See more keywords
Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma
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DOI: 10.7554/elife.76294
Abstract: Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell… read more here.
Keywords: hepatocellular carcinoma; signalling intensity; intensity; mapk signalling ... See more keywords