MAPK‐Targeted Drug Delivered by a pH‐Sensitive MSNP Nanocarrier Synergizes with PD‐1 Blockade in Melanoma without T‐Cell Suppression
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DOI: 10.1002/adfm.201806916
Abstract: The combination of BRAF/MEK‐targeted therapy with immune checkpoint blockade is regarded as a promising regimen for patients with metastatic melanoma due to their complementary advantages. However, MEK‐inhibitor‐induced T‐cell toxicity impedes effective cooperation. In this experiment,… read more here.
Keywords: mapk targeted; mek inhibitor; suppression; inhibitor ... See more keywords
Transcriptome-wide decoding the roles of aberrant splicing in melanoma MAPK-targeted resistance evolution
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DOI: 10.1038/s44319-025-00521-6
Abstract: Drug resistance critically limits the long-term efficacy of MAPK-targeted therapy in melanoma. While resistance mechanisms at genetic, epigenetic, and transcriptional scales are well-documented, post-transcriptional splicing regulation remains poorly understood. By analyzing patient-matched pre-treatment and resistant… read more here.
Keywords: mapk targeted; resistance; akt2; melanoma ... See more keywords