Mapping the Binding Energy of Layered Crystals to Macroscopic Observables
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DOI: 10.1002/advs.202204001
Abstract: Van der Waals (vdW) integration of two dimensional (2D) crystals into functional heterostructures emerges as a powerful tool to design new materials with fine‐tuned physical properties at an unprecedented precision. The intermolecular forces governing the… read more here.
Keywords: energy layered; binding energy; mapping binding; layered crystals ... See more keywords
Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6
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DOI: 10.1002/cmdc.202100683
Abstract: Cyclooxygenase‐2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG‐Gs) from 2‐arachidonoylglycerol. PG‐Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular… read more here.
Keywords: ester; receptor p2y6; mapping binding; p2y6 ... See more keywords
Epitope Mapping and Binding Assessment by Solid-State NMR Provide a Way for the Development of Biologics under the Quality by Design Paradigm
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DOI: 10.1021/jacs.2c03232
Abstract: Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic efficacy and safety. Epitope mapping… read more here.
Keywords: mapping binding; solid state; epitope mapping; state nmr ... See more keywords