The role of NMR spectroscopy in mapping the conformational landscape of GPCRs.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.03.030
Abstract: Over recent years, nuclear magnetic resonance (NMR) spectroscopy has developed into a powerful mechanistic tool for the investigation of G protein-coupled receptors (GPCRs). NMR provides insights which underpin the dynamic nature of these important receptors… read more here.
Keywords: mapping conformational; nmr spectroscopy; landscape; role nmr ... See more keywords
Computational Mapping of Conformational Dynamics and Interaction Hotspots of Human VISTA with pH-Selective Antibodies.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00863
Abstract: The V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative immune checkpoint protein that regulates T-cell-mediated anticancer immune responses, making it a promising target for immunotherapy. Unlike other checkpoint proteins, VISTA activity is… read more here.
Keywords: dynamics interaction; computational mapping; mapping conformational; vista selective ... See more keywords
Mapping Conformational and Kinetic Landscapes of 14-3-3σ/α-Synuclein Assembly via Variational Autoencoders and Markov State Models.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c02323
Abstract: The interaction between the molecular chaperone 14-3-3σ and the intrinsically disordered protein α-synuclein is implicated in the pathogenesis of Parkinson's disease, yet its dynamic mechanism remains poorly understood at an atomistic level. The inherent flexibility… read more here.
Keywords: synuclein assembly; mapping conformational; variational autoencoders; state models ... See more keywords