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Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa148
Abstract: While thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step. We review the standard fine-mapping approach, which is computationally fast…
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Keywords:
mapping genetic;
genetic associations;
fine mapping;
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Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0680-4
Abstract: The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated…
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Keywords:
mapping genetic;
combination therapies;
rational combination;
genetic interactions ... See more keywords
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Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00603
Abstract: Genomic scans for signatures of selection allow us to, in principle, detect variants and genes that underlie recent adaptations. By combining selection mapping with genetic mapping of traits known to be relevant to adaptation, we…
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Keywords:
mapping genetic;
mapping;
genetic mapping;
selection ... See more keywords
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2
Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.890590
Abstract: Genetic mutation and recombination are driving the evolution of SARS-CoV-2, leaving many genetic imprints which could be utilized to track the evolutionary pathway of SARS-CoV-2 and explore the relationships among variants. Here, we constructed a…
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Keywords:
cov variants;
recombination;
mapping genetic;
events sars ... See more keywords