Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70688
Abstract: While prior studies have identified regional reduction in gray matter (GM) volume in schizophrenia, it remains unclear whether these alterations are concentrated in specific brain functional areas and how they relate to genetic factors. This… read more here.
Keywords: associations functional; brain; genetic associations; cortical development ... See more keywords
Fine-mapping genetic associations.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa148
Abstract: While thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step. We review the standard fine-mapping approach, which is computationally fast… read more here.
Keywords: mapping genetic; genetic associations; fine mapping;
Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1101/2025.02.26.640314
Abstract: Cellular iron levels must be tightly regulated to ensure sufficient iron for essential enzymatic functions whilst avoiding the harmful generation of toxic species. Here, to better understand how iron levels are controlled, we carry out… read more here.
Keywords: flux; landscape iron; iron; mapping genetic ... See more keywords
Mapping genetic interactions in cancer: a road to rational combination therapies
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0680-4
Abstract: The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated… read more here.
Keywords: mapping genetic; combination therapies; rational combination; genetic interactions ... See more keywords
Integrating Selection Mapping With Genetic Mapping and Functional Genomics
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00603
Abstract: Genomic scans for signatures of selection allow us to, in principle, detect variants and genes that underlie recent adaptations. By combining selection mapping with genetic mapping of traits known to be relevant to adaptation, we… read more here.
Keywords: mapping genetic; mapping; genetic mapping; selection ... See more keywords
Mapping Genetic Events of SARS-CoV-2 Variants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.890590
Abstract: Genetic mutation and recombination are driving the evolution of SARS-CoV-2, leaving many genetic imprints which could be utilized to track the evolutionary pathway of SARS-CoV-2 and explore the relationships among variants. Here, we constructed a… read more here.
Keywords: cov variants; recombination; mapping genetic; events sars ... See more keywords