Abstract 214: Patient-specific mapping of oncogenic structural changes in pediatric osteosarcoma
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DOI: 10.1158/1538-7445.am2023-214
Abstract: We have leveraged long-read and spatial sequencing modalities to identify patient-specific oncogenic alterations for treatment of pediatric osteosarcomas. Osteosarcoma (OS) is the most common primary bone malignancy in children and young adults, with over 500… read more here.
Keywords: osteosarcoma; mapping oncogenic; svs; patient specific ... See more keywords
Abstract 2775: High-resolution mapping of oncogenic structural changes in osteosarcoma
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DOI: 10.1158/1538-7445.am2025-2775
Abstract: We have leveraged long-read and spatial sequencing modalities to identify cancer-specific oncogenic alterations for treatment of osteosarcomas. Osteosarcoma is archetypal of cancers driven by aneuploidy and structural rearrangement rather than point mutations. The functional consequences… read more here.
Keywords: cancer; cell lines; mapping oncogenic; resolution mapping ... See more keywords