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   Articles with "mapt" as a keyword



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Expanding MAPT p.V363I Mutation Phenotype: An Overlapping of PSP‐CBS and Posterior Cortical Atrophy

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recommendations! Published in 2023 at "Movement Disorders Clinical Practice"

DOI: 10.1002/mdc3.13671

Abstract: Mutations in the microtubule-associated protein tau gene ( MAPT ) are associated with heterogeneous clinical and patholog-ical manifestations read more here.

Keywords: mapt v363i; expanding mapt; phenotype overlapping; v363i mutation ... See more keywords
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BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1580096

Abstract: ABSTRACT A major cellular catabolic pathway in neurons is macroautophagy/autophagy, through which misfolded or aggregation-prone proteins are sequestered into autophagosomes that fuse with lysosomes, and are degraded. MAPT (microtubule-associated protein tau) is one of the… read more here.

Keywords: protein; microtubule associated; bag3; synpo synaptopodin ... See more keywords
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Retromer regulates the lysosomal clearance of MAPT/tau

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recommendations! Published in 2020 at "Autophagy"

DOI: 10.1080/15548627.2020.1821545

Abstract: ABSTRACT The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset… read more here.

Keywords: mapt tau; aggregation; retromer; clearance ... See more keywords
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Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2095791

Abstract: ABSTRACT Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of… read more here.

Keywords: mapt tau; activity; stimulation; pathological mapt ... See more keywords
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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci

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recommendations! Published in 2022 at "Brain"

DOI: 10.1093/brain/awac325

Abstract: Abstract Parkinson’s disease is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies has considerably advanced our understanding of the Parkinson’s disease genetic risk. Understanding the functional significance of the… read more here.

Keywords: disease; parkinson disease; mapt; genetic risk ... See more keywords
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Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women.

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recommendations! Published in 2021 at "Journal of applied physiology"

DOI: 10.1152/japplphysiol.00653.2021

Abstract: The cerebral pressure-flow relationship has directional sensitivity, meaning the augmentation in cerebral blood flow is attenuated when mean arterial pressure (MAP) increases vs MAP decreases. We employed repeated squat-stands (RSS) to quantify it using a… read more here.

Keywords: mcavt mapt; pressure; flow; diurnal variation ... See more keywords
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Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

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recommendations! Published in 2017 at "Molecular Neurodegeneration"

DOI: 10.1186/s13024-017-0224-6

Abstract: BackgroundGenome wide association studies have identified microtubule associated protein tau (MAPT) H1 haplotype single nucleotide polymorphisms (SNPs) as leading common risk variants for Parkinson’s disease, progressive supranuclear palsy and corticobasal degeneration. The MAPT risk variants… read more here.

Keywords: haplotype specific; mapt exon; expression; mapt ... See more keywords
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Transcript Variants of Genes Involved in Neurodegeneration Are Differentially Regulated by the APOE and MAPT Haplotypes

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recommendations! Published in 2021 at "Genes"

DOI: 10.3390/genes12030423

Abstract: Genetic variations at the Apolipoprotein E (ApoE) and microtubule-associated protein tau (MAPT) loci have been implicated in multiple neurogenerative diseases, but their exact molecular mechanisms are unclear. In this study, we performed transcript level linear… read more here.

Keywords: mapt haplotypes; transcript variants; neurodegeneration; apoe mapt ... See more keywords
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Bigelovin inhibits hepatocellular carcinoma cell growth and metastasis by regulating the MAPT-mediated Fas/FasL pathway.

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recommendations! Published in 2023 at "Neoplasma"

DOI: 10.4149/neo_2023_221125n1132

Abstract: Bigelovin (BigV), as traditional Chinese medicine, has been shown to inhibit the malignant progression of hepatocellular carcinoma (HCC). This study aimed to investigate whether BigV affects the development of HCC by targeting the MAPT and… read more here.

Keywords: cell; hcc; fas fasl; mapt ... See more keywords