In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.683
Abstract: Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre‐symptomatic carrier of the… read more here.
Keywords: neuroinflammation; carrier; pre symptomatic; mapt mutation ... See more keywords
Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimaging"
DOI: 10.1111/jon.12642
Abstract: The objective of this study was to longitudinally investigate the trajectory of change in 1H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow‐up, and to determine the time at which the… read more here.
Keywords: brain spectroscopy; mutation carriers; spectroscopy changes; spectroscopy ... See more keywords