Retromer regulates the lysosomal clearance of MAPT/tau
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1821545
Abstract: ABSTRACT The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset… read more here.
Keywords: mapt tau; aggregation; retromer; clearance ... See more keywords
Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046437
Abstract: ABSTRACT Alzheimer disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited and thus the discovery of novel anti-AD agents is urgently needed. A key pathological hallmark of AD… read more here.
Keywords: tau; mapt tau; alzheimer disease; transcription factor ... See more keywords
Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2095791
Abstract: ABSTRACT Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of… read more here.
Keywords: mapt tau; activity; stimulation; pathological mapt ... See more keywords
MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2018.6896
Abstract: The association of MAPT (Tau) with various tauopathies and other neurological disorders has long been established. However, the role of microtubule‑associated protein Tau (MAPT) expression in brain cancer is largely unknown. To determine whether MAPT… read more here.
Keywords: mapt tau; grade glioma; expression; low grade ... See more keywords