A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome
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DOI: 10.1007/s11064-020-03050-x
Abstract: Inhibition of immune and inflammatory reaction induced by the expose of nucleus pulposus (NP) could effectively ameliorate neuropathic pain in the lumbar disc herniation. Maresin1 (MaR1), as a macrophage-derived mediator of inflammation resolution, displayed potent… read more here.
Keywords: mar1; radicular pain; interaction; nlrp3 inflammasome ... See more keywords
Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy
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DOI: 10.1038/s41598-017-11188-y
Abstract: The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with… read more here.
Keywords: mar1; stromal cells; epi lxa4; patients chronic ... See more keywords
The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206480120
Abstract: The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation and enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncytial virus (RSV)-induced inflammation.… read more here.
Keywords: inflammation; syncytial virus; maresin; lgr6 ... See more keywords
Maresin 1 attenuates pro‐inflammatory activation induced by β‐amyloid and stimulates its uptake
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16098
Abstract: Alzheimer's disease (AD) is the most common dementia, characterized by pathological accumulation of β‐amyloid (Aβ) and hyperphosphorylation of tau protein, together with a damaging chronic inflammation. The lack of effective treatments urgently warrants new therapeutic… read more here.
Keywords: inflammatory activation; mar1; pro resolving; activation ... See more keywords
Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway
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DOI: 10.1155/2022/7177889
Abstract: Background. Chronic hyperglycemia-induced inflammation is recognized as the most important pathophysiological process in diabetic kidney disease (DKD). As maresin 1 (MaR1) is an extensive anti-inflammatory lipid mediator, the present study investigated the protective role of… read more here.
Keywords: dkd; via lgr6; mar1; kidney disease ... See more keywords
Low serum Maresin-1 levels are associated with non-alcoholic fatty liver disease: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2021 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-021-01518-5
Abstract: Background Maresin-1 (MaR1) is an anti-inflammatory pro-resolving mediator and is considered a potential regulator of metabolic diseases. Non-alcoholic fatty liver disease (NAFLD) is a very common metabolic liver disease. However, little information is available on… read more here.
Keywords: liver disease; serum mar1; mar1; mar1 levels ... See more keywords
Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02386-1
Abstract: Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated… read more here.
Keywords: mar1; administration; experimental autoimmune; inflammation ... See more keywords