Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
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DOI: 10.1021/acs.jmedchem.7b01593
Abstract: Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising… read more here.
Keywords: deacetylase inhibitors; marbostat 100; potent selective; histone deacetylase ... See more keywords