Marburg virus‐like particles produced in insect cells induce neutralizing antibodies in rhesus macaques
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24832
Abstract: Marburg virus (MARV), which is one of the most virulent agents in the world, causes lethal haemorrhagic fever in humans and nonhuman primates (NHPs) with a mortality rate of up to 90%. Currently, there is… read more here.
Keywords: marburg virus; marv; virus like; rhesus macaques ... See more keywords
In Vivo Bioluminescent Imaging of Marburg Virus in a Rodent Model.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9940-8_12
Abstract: Pseudoviruses are useful tools because of their safety and versatility compared to wild type viruses. Optical imaging of reporter gene labeled pseudoviruses in small animal models can allow for real-time analysis of the infection process… read more here.
Keywords: marburg virus; imaging marburg; bioluminescent imaging; vivo bioluminescent ... See more keywords
Ebola and Marburg virus vaccines
Sign Up to like & getrecommendations! Published in 2017 at "Virus Genes"
DOI: 10.1007/s11262-017-1455-x
Abstract: The filoviruses, Ebola virus (EBOV), and Marburg virus (MARV), are among the most pathogenic viruses known to man and the causative agents of viral hemorrhagic fever outbreaks in Africa with case fatality rates of up… read more here.
Keywords: marburg virus; ebov marv; virus; ebola marburg ... See more keywords
Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00184-3
Abstract: Marburg virus (MARV) belongs to the Filoviridae family, along with the related Ebola virus (EBOV). Although MARV is less renowned than EBOV, it causes an equally devastating disease, with clinical symptoms similar to EBOV infection… read more here.
Keywords: marburg virus; marv; approved drugs; screen ... See more keywords
Conformational and lipid bilayer-perturbing properties of Marburg virus GP2 segments containing the fusion loop and membrane-proximal external region/transmembrane domain
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e03018
Abstract: Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the… read more here.
Keywords: marburg virus; gp2; membrane proximal; fusion ... See more keywords
Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14327-8
Abstract: Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat… read more here.
Keywords: marburg virus; egyptian rousette; virus; west africa ... See more keywords
Immune correlates of postexposure vaccine protection against Marburg virus
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DOI: 10.1038/s41598-020-59976-3
Abstract: Postexposure immunization can prevent disease and reduce transmission following pathogen exposure. The rapid immunostimulatory properties of recombinant vesicular stomatitis virus (rVSV)-based vaccines make them suitable postexposure treatments against the filoviruses Ebola virus and Marburg virus… read more here.
Keywords: marburg virus; protection; correlates postexposure; immune correlates ... See more keywords
From hybridomas to a robust microalgal-based production platform: molecular design of a diatom secreting monoclonal antibodies directed against the Marburg virus nucleoprotein
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0745-2
Abstract: BackgroundThe ideal protein expression system should provide recombinant proteins in high quality and quantity involving low production costs only. However, especially for complex therapeutic proteins like monoclonal antibodies many challenges remain to meet this goal… read more here.
Keywords: marburg virus; hybridomas robust; production; monoclonal antibodies ... See more keywords
Marburg virus pathogenesis – differences and similarities in humans and animal models
Sign Up to like & getrecommendations! Published in 2019 at "Virology Journal"
DOI: 10.1186/s12985-019-1272-z
Abstract: Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities… read more here.
Keywords: marburg virus; differences similarities; virus pathogenesis; pathogenesis differences ... See more keywords
An introduction to the Marburg virus vaccine consortium, MARVAC
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DOI: 10.1371/journal.ppat.1010805
Abstract: The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine “MARVAC” consortium representing leaders in the field of vaccine research and development aiming to facilitate a rapid response… read more here.
Keywords: marvac; marburg virus; marburg; vaccine ... See more keywords
Natural History of Marburg Virus Infection to Support Medical Countermeasure Development
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DOI: 10.3390/v14102291
Abstract: The Biomedical Advanced Research and Development Authority, part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, recognizes that the evaluation of medical countermeasures under the Animal… read more here.
Keywords: natural history; development; marburg virus;