MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K‐AKT‐β‐catenin pathways
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DOI: 10.1111/jcmm.14235
Abstract: Membrane‐associated RING‐CH‐1 (MARCH1) is a membrane‐anchored E3 ubiquitin ligase that is involved in a variety of cellular processes. MARCH1 was aberrantly expressed as a tumour promoter in ovarian cancer, but the signalling about the molecular… read more here.
Keywords: hepatocellular carcinoma; carcinoma; pi3k akt; march1 ... See more keywords
The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01806-21
Abstract: Iron is essential for cells, playing important roles in energy generation, DNA replication, and gene expression. During infection, HCMV alters many cellular processes to aid its replication. ABSTRACT Human cytomegalovirus (HCMV) modulates numerous cellular pathways… read more here.
Keywords: march1; iron; infection; many cellular ... See more keywords
March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/3823910
Abstract: Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of… read more here.
Keywords: features allergic; inflammation; march1; march1 ubiquitin ... See more keywords
MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway
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DOI: 10.1371/journal.pone.0200540
Abstract: Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I.… read more here.
Keywords: march1; expression; mhc; impacts mhc ... See more keywords
The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
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DOI: 10.1371/journal.pone.0204898
Abstract: Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING-CH-1 (MARCH1) is an… read more here.
Keywords: ubiquitin ligase; sex specific; march1; march1 mice ... See more keywords
Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain
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DOI: 10.3390/v14112549
Abstract: MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict replication of certain viruses. While the antiviral activity of MARCH8 has been intensively studied, less is… read more here.
Keywords: ability; terminal cytoplasmic; march1; differences terminal ... See more keywords
Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy
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DOI: 10.7150/thno.78851
Abstract: Background: The therapeutic efficacy of allergen specific immunotherapy (SIT) is recognized, but needs improved. Psychological stress influences the immune system's function. The objective of this study is to elucidate the effects of psychological stress on… read more here.
Keywords: stress; sit; march1; efficacy ... See more keywords