Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac215
Abstract: Abstract As the most abundant organelles in oocytes, mitochondria play an important role in maintaining oocyte quality. Here, we report that March5, encoding a mitochondrial ubiquitin ligase that promotes mitochondrial elongation, plays a critical role… read more here.
Keywords: maturation; meiotic maturation; mitochondrial ubiquitin; oocyte meiotic ... See more keywords
march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos
Sign Up to like & getrecommendations! Published in 2020 at "Molecules and Cells"
DOI: 10.14348/molcells.2019.0210
Abstract: MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in… read more here.
Keywords: march5; telencephalon diencephalon; extension movement; zebrafish embryos ... See more keywords
Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5.
Sign Up to like & getrecommendations! Published in 2022 at "Life science alliance"
DOI: 10.26508/lsa.202101309
Abstract: Mitochondrial homeostasis is tightly controlled by ubiquitination. The mitochondrial integral membrane ubiquitin ligase MARCH5 is a crucial regulator of mitochondrial membrane fission, fusion, and disposal through mitophagy. In addition, the lipid composition of mitochondrial membranes… read more here.
Keywords: ligase march5; march5; activity; membrane ... See more keywords
Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer
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DOI: 10.3390/biomedicines9101329
Abstract: E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human MARCH5 gene. The main objective of this study was to visualize the prognosis of MARCH5 in breast… read more here.
Keywords: march5; march5 expression; breast cancer;
MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation
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DOI: 10.7554/elife.54954
Abstract: MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer… read more here.
Keywords: mcl1 degradation; response; march5; integrated stress ... See more keywords