Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.10.031
Abstract: Epithelial-mesenchymal transition (EMT) is linked to fibrosis following exposure to silica. The scavenger receptor, macrophage receptor with collagenous structure (MARCO) plays an important role in silica-induced inflammation, however, the effect of MARCO on silica-induced fibrosis… read more here.
Keywords: mesenchymal transition; fibrosis; marco; silica induced ... See more keywords
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function
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DOI: 10.1158/0008-5472.can-20-1885
Abstract: This study defines tumor-derived IL37 and the macrophage scavenger receptor MARCO as potential therapeutic targets to remodel the immune-suppressive microenvironment in patients with lung cancer. The progression and metastatic capacity of solid tumors are strongly… read more here.
Keywords: lung cancer; cancer; cell; tumor ... See more keywords
Airway autoantibodies are determinants of asthma severity
Sign Up to like & getrecommendations! Published in 2022 at "European Respiratory Journal"
DOI: 10.1183/13993003.00442-2022
Abstract: Background Local airway autoimmune responses may contribute to steroid dependence and persistent eosinophilia in severe asthma. Auto-IgG antibodies directed against granule proteins such as eosinophil peroxidase (EPX), macrophage scavenger receptor with collagenous structure (MARCO) and… read more here.
Keywords: patients airway; asthmatic patients; airway; marco ... See more keywords
Cómo se construye el marco teórico de la investigación
Sign Up to like & getrecommendations! Published in 2018 at "Cadernos De Pesquisa"
DOI: 10.1590/198053145177
Abstract: espanolEste articulo tiene una finalidad practica: presentar a los estudiantes e investigadores un grupo de estrategias que les faciliten la construccion del marco teorico y su articulacion con las otras partes de la investigacion. El… read more here.
Keywords: marco; marco rico; rico investigaci; marco teorico ... See more keywords
MARCO is a potential prognostic and immunotherapy biomarker.
Sign Up to like & getrecommendations! Published in 2023 at "International immunopharmacology"
DOI: 10.2139/ssrn.4204643
Abstract: BACKGROUND Macrophage receptor with collagenous structure (MARCO), a novel immune checkpoint expressed on tumor-associated macrophages, has antitumor therapeutic properties. However, the association between MARCO and patient prognosis, immune infiltration, and ICI immunotherapy needs to be… read more here.
Keywords: prognosis; immunotherapy; expression; marco ... See more keywords
Problems associated with applicability of the stand-scale vegetation reconstruction model MARCO POLO: A case study in the Qaidam Basin
Sign Up to like & getrecommendations! Published in 2019 at "Acta Ecologica Sinica"
DOI: 10.5846/stxb201806011222
Abstract: 立地尺度植被定量重建是对利用孢粉进行古气候和古环境研究的一个重要补充。一些新的定量重建模型相继提出，但其适用性仍需进一步验证。以柴达木盆地24个样方表土孢粉及4个湖泊表层沉积孢粉为研究对象，利用MARCO POLO模型重建立地尺度植被盖度并分析该模型的适用性。研究结果表明，由于地形开阔且风力较大，干旱区的大型湖泊沉积物中往往容易富集超代表性孢粉，使这些孢粉的区域信号增强，从而降低孢粉类型筛选的正确率。若湖泊与样方间的距离较近，湖泊表层孢粉能够更好地反映样方所在区域的孢粉特征，则有利于提高孢粉类型筛选的正确率。MARCO POLO模型中的孢粉代表性R值是将孢粉含量转化为植被盖度的关键参数。由于受到孢粉自身生产、传播、保存以及外部环境等多方面因素的影响，不同样方的R值可能差异很大。因此在运行该模型前需保证R值能够准确反映立地尺度中各孢粉类型与植被盖度的关系。仅在以柴达木盆地为代表的干旱区对该模型进行检验，今后仍需要在不同植被或气候区进行深入研究以全面了解该模型的适用条件。 read more here.
Keywords: applicability stand; marco polo; problems associated; marco ... See more keywords