Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03477-z
Abstract: Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens. Although Marek’s disease (MD) is well controlled by current vaccines, the… read more here.
Keywords: marek disease; immunity; mdv; cell ... See more keywords
Modeling Marek’s disease virus transmission: A framework for evaluating the impact of farming practices and evolution
Sign Up to like & getrecommendations! Published in 2018 at "Epidemics"
DOI: 10.1016/j.epidem.2018.01.001
Abstract: Marek’s disease virus (MDV) is a pathogen of chickens whose control has twice been undermined by pathogen evolution. Disease ecology is believed to be the main driver of this evolution, yet mathematical models of MDV… read more here.
Keywords: farming practices; marek disease; disease virus; virus ... See more keywords
A comparison of exosome purification methods using serum of Marek's disease virus (MDV)-vaccinated and -tumor-bearing chickens
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05669
Abstract: Marek's disease (MD) is an alphaherpesvirus (Marek's disease virus, MDV)-induced pathology of chickens associated with paralysis, immunosuppression, neurological signs, and T-cell lymphomas. MD is controlled in poultry production via live attenuated vaccines. The purpose of… read more here.
Keywords: marek disease; disease virus; tumor bearing; disease ... See more keywords
In ovo administration of Toll-like receptor ligands encapsulated in PLGA nanoparticles impede tumor development in chickens infected with Marek's disease virus.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.05.091
Abstract: One of the economically important diseases in the poultry industry is Marek's disease (MD) which is caused by Marek's disease virus (MDV). The use of current vaccines provides protection against clinical signs of MD in… read more here.
Keywords: toll like; marek disease; disease virus; development ... See more keywords
Differential expression of type I interferon mRNA and protein levels induced by virulent Marek's disease virus infection in chickens.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2019.04.010
Abstract: Marek's disease virus (MDV), an α-herpesvirus targeting avian species, causes fatal Marek's disease (MD) in chickens. The host interferon (IFN) responses play a key role in resisting viral infection. However, host IFN responses following MDV… read more here.
Keywords: expression; marek disease; infection; mdv ... See more keywords
Marek's disease vaccines: Current status, and strategies for improvement and development of vector vaccines.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2016.11.024
Abstract: Marek's disease (MD) is a lymphoproliferative viral disease of chickens, which has been controlled through vaccination since 1969. MD vaccines protect against tumors but do not provide sterilizing immunity, and thus it is generally believed… read more here.
Keywords: vector vaccines; marek disease; current status; development ... See more keywords
Vertical transmission of ALV from ALV-J positive parents caused severe immunosuppression and significantly reduced marek's disease vaccine efficacy in three-yellow chickens.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2020.108683
Abstract: In order to evaluate the influence of the vertical transmission of avian leukosis virus (ALV) from J subgroup (ALV-J) positive parents on the vaccine efficacy of Marek's disease virus (MDV), ALV-J positive male breeders ×… read more here.
Keywords: alv positive; marek disease; vaccine efficacy; vertical transmission ... See more keywords
Expression of Marek's Disease Virus Oncoprotein Meq During Infection in the Natural Host.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.01.011
Abstract: Gallid herpesvirus 2 (Marek's disease virus, MDV) causes lymphoproliferative Marek's disease (MD), and is unique among alphaherpesviruses as the viral genome encodes an oncoprotein, Meq. To elucidate the temporal relationship between Meq expression and the… read more here.
Keywords: marek disease; expression; disease virus;
scRNA seq of an F1 cross of Marek’s disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators
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DOI: 10.1038/s41598-025-86174-w
Abstract: Marek’s disease (MD), a T cell lymphoma disease in chickens, is caused by the Marek’s disease virus (MDV) found ubiquitously in the poultry industry. Genetically resistant Line 63 (L6) and susceptible Line 72 (L7) chickens… read more here.
Keywords: disease; marek disease; cell; immune cell ... See more keywords
Emerging natural recombinant Marek's disease virus between vaccine and virulence strains and their pathogenicity.
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DOI: 10.1111/tbed.14506
Abstract: Marek's disease virus (MDV), an oncogenic virus belonging to the subfamily Alphaherpesvirinae, causes Marek's disease (MD). Vaccines can control MD, but cannot block the viral infection; they are considered imperfect vaccines, which carry the risk… read more here.
Keywords: 0803 1307; natural recombinant; virulence; marek disease ... See more keywords
Genetic characterization of Marek's disease virus in chickens in Thailand reveals high genetic diversity of circulating strains.
Sign Up to like & getrecommendations! Published in 2022 at "Transboundary and emerging diseases"
DOI: 10.1111/tbed.14748
Abstract: Marek's disease (MD) is a highly contagious lymphoproliferative disease of chickens caused by Gallid alphaherpesvirus 2 (GaHV-2), commonly known as serotype 1 Marek's disease virus (MDV-1). Despite widespread vaccination, MD related cases have been frequently… read more here.
Keywords: disease; field strains; mdv field; marek disease ... See more keywords