The Arrangement of Microtubules in the Platelet Marginal Band
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620015962
Abstract: During thrombosis, platelets must undergo a drastic change in shape over a short period of time [1]. In their inactive state they are discoid, after activation, platelets become a tight circular shape and then flatten… read more here.
Keywords: shape; arrangement microtubules; band; platelet marginal ... See more keywords
Marginal band microtubules are acetylated by αTAT1
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1759791
Abstract: Abstract The discoid shape of resting platelets is maintained by a peripheral, circular bundle of microtubules called marginal band. Marginal band microtubules are acetylated on lysine 40 of the alpha-tubulin subunits. We have previously shown… read more here.
Keywords: band microtubules; microtubules acetylated; acetylation; marginal band ... See more keywords
Loss of α4A- and β1-tubulin leads to severe platelet spherocytosis and strongly impairs hemostasis in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016729
Abstract: Native circulating blood platelets present with a discoid flat morphology maintained by a sub-membranous peripheral ring of microtubules, named marginal band. The functional importance of this particular shape is still debated, but was initially hypothesized… read more here.
Keywords: tubulin; loss tubulin; marginal band; hemostasis ... See more keywords