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   Articles with "maribavir" as a keyword



Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open‐Label, Single‐Dose, Parallel Group Study

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recommendations! Published in 2022 at "Journal of Clinical Pharmacology"

DOI: 10.1002/jcph.2155

Abstract: Maribavir, an orally bioavailable antiviral, has shown superior activity against posttransplant cytomegalovirus infection compared with conventional antivirals. It is primarily metabolized in the liver. This open‐label, single‐center study evaluated the effect of hepatic impairment on… read more here.

Keywords: participants moderate; hepatic impairment; maribavir; impairment ... See more keywords
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Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing.

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recommendations! Published in 2021 at "Antiviral research"

DOI: 10.1016/j.antiviral.2021.105139

Abstract: Because ganciclovir resistance mutations in the cytomegalovirus UL97 gene most commonly occur at codons 460, 520 and 590-607, diagnostic genotyping for drug resistance has often omitted the analysis of codons below 440. However, the UL97… read more here.

Keywords: binding region; maribavir; ganciclovir maribavir; atp binding ... See more keywords

Summary of Maribavir (SHP620) Drug–Drug Interactions Based on Accumulated Clinical and Nonclinical Data

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recommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"

DOI: 10.1016/j.bbmt.2018.12.600

Abstract: Introduction Maribavir, a potent and orally bioavailable antiviral, is being evaluated in Phase 3 trials for the treatment of cytomegalovirus (CMV) infections in transplant patients. Often numerous concomitant medications are administered to these patients to… read more here.

Keywords: drug interactions; drug; summary maribavir; maribavir ... See more keywords

Maribavir for Cytomegalovirus Treatment in the Real World—Not a Silver Bullet

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recommendations! Published in 2022 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofac686

Abstract: TO THE EDITOR—Cytomegalovirus (CMV) infection remains a frequent cause of morbidity and mortality among stem-cell and solid organ transplant recipients, with devastating complications including graft failure and death [1, 2]. Limitations of existing anti-CMV agents… read more here.

Keywords: maribavir cytomegalovirus; maribavir; cmv infection; treatment ... See more keywords

Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi–Physiologically Based Modeling Approaches

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recommendations! Published in 2021 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.121.000493

Abstract: Maribavir is in phase 3 clinical development for treatment of cytomegalovirus infection/disease in transplant recipients. Previous research conducted using only intact cynomolgus monkeys indicated biliary secretion as the primary elimination pathway for maribavir and that… read more here.

Keywords: maribavir; mass balance; semi; physiologically based ... See more keywords

Single-center retrospective analysis of maribavir in the treatment of refractory and drug-intolerant cytomegalovirus viremia and cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-6059

Abstract: Background Cytomegalovirus (CMV) infection is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) that significantly impacts prognosis and can even be life-threatening. CMV infection increases non-relapse mortality (NRM), the incidence of graft-versus-host disease… read more here.

Keywords: disease; maribavir; cmv; cytomegalovirus ... See more keywords

Dual Resistance to Maribavir and Ganciclovir in Transplant Recipients

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recommendations! Published in 2025 at "Viruses"

DOI: 10.3390/v17030421

Abstract: Background: Human cytomegalovirus (CMV) remains an important pathogen, especially for immunocompromised patients such as solid organ and hematopoietic stem cell recipients. Viral genomic mutations conferring drug resistance are an important impediment to effective CMV management… read more here.

Keywords: resistance; mbv resistance; maribavir; cmv ... See more keywords