Inhibition of NF‐&kgr;B‐dependent HIV‐1 replication by the marine natural product bengamide A
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.02.017
Abstract: ABSTRACT HIV‐1 inhibitors that act by mechanisms distinct from existing antiretrovirals can provide novel insights into viral replication and potentially inform development of new therapeutics. Using a multi‐cycle HIV‐1 replication assay, we screened 252 pure… read more here.
Keywords: hiv replication; marine natural; hiv; expression ... See more keywords
Modulation of the ubiquitin-proteasome system by marine natural products
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101897
Abstract: The ubiquitin-proteasome system (UPS) is a key player in the maintenance of cellular protein homeostasis (proteostasis). Since proteasome function declines upon aging leading to the acceleration of its progression and the manifestation of age-related pathologies,… read more here.
Keywords: marine natural; proteasome system; modulation ubiquitin; system marine ... See more keywords
Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00007
Abstract: ConspectusAntimicrobial resistance to existing antibiotics represents one of the greatest threats to human health and is growing at an alarming rate. To further complicate treatment of bacterial infections, many chronic infections are the result of… read more here.
Keywords: natural products; marine natural; microbiology; resistance ... See more keywords
Marine Natural Products as Leads against SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c00015
Abstract: Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent… read more here.
Keywords: natural products; infection; products leads; marine natural ... See more keywords
Genome mining as a biotechnological tool for the discovery of novel marine natural products
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2020.1751056
Abstract: Abstract Compared to terrestrial environments, the oceans harbor a variety of environments, creating higher biodiversity, which gives marine natural products a high occurrence of significant biology and novel chemistry. However, traditional bioassay-guided isolation and purification… read more here.
Keywords: novel marine; mining; natural products; marine natural ... See more keywords
Concise synthesis of marine natural products smenodiol and (−)-pelorol
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2021.2023871
Abstract: Abstract A facile synthesis of marine natural product smenodiol has been achieved in 23.2% overall yield within 8 steps from readily available starting materials, which facilitates a concise synthesis of the marine natural product (−)-pelorol… read more here.
Keywords: marine natural; pelorol; concise synthesis; natural product ... See more keywords
Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.841941
Abstract: Toxoplasmosis, caused by Toxoplasma gondii, is a common disease worldwide and could be severe and even fatal in immunocompromised individuals and fetuses. Limitation in current available treatment options drives the need to develop novel therapeutics.… read more here.
Keywords: benzoate octyl; natural products; marine natural; estradiol benzoate ... See more keywords
Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR)
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10030337
Abstract: Marine natural products (MNPs) have been an important and rich source for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein, we report bioassay guided fractionation of marine extracts from sponges… read more here.
Keywords: activity relationships; natural products; marine natural; structure activity ... See more keywords
Marine Natural Compounds with Biomedical Potential
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091242
Abstract: Marine organisms are an inexhaustible source of natural compounds that are promising for the creation of drugs or biologically active additives, which is closely related to the huge biological diversity of the resources of the… read more here.
Keywords: compounds biomedical; biomedical potential; natural compounds; marine natural ... See more keywords
Promising Activities of Marine Natural Products against Hematopoietic Malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9060645
Abstract: According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side… read more here.
Keywords: promising activities; activities marine; natural products; marine natural ... See more keywords
A Two-Zone Combustion Model for Knocking Prediction of Marine Natural Gas SI Engines
Sign Up to like & getrecommendations! Published in 2018 at "Energies"
DOI: 10.3390/en11030561
Abstract: The further thermal efficiency improvement of marine natural gas engine is constrained by a knocking phenomenon that commonly occurs in gas-fueled spark-ignited engines. It plays an important role to investigate how the knocking occurs and… read more here.
Keywords: two zone; marine natural; engine; gas ... See more keywords