A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues
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DOI: 10.1002/ddr.22006
Abstract: Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine sponge alkaloid analogues with 2‐amino‐1H‐imidazol (2‐AI) core. Cytotoxicity was tested on murine 4T1 breast cancer, A549 human lung cancer, and HL‐60… read more here.
Keywords: alkaloid analogues; marine sponge; cancer; sponge alkaloid ... See more keywords
Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.
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DOI: 10.1007/s11418-017-1157-7
Abstract: Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were elucidated on the basis of… read more here.
Keywords: okinawan marine; diterpene alkaloids; sponge agelas; agelamasines diterpene ... See more keywords
Two new pyrrolo-2-aminoimidazoles from a Myanmarese marine sponge, Clathria prolifera
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1205-y
Abstract: Marine organisms such as marine sponges and soft corals are valuable sources of pharmacologically active secondary metabolites. In our ongoing research on the discovery of new secondary metabolites from marine organisms, two new pyrrolo-2-aminoimidazoles, clathriroles… read more here.
Keywords: sponge; two new; pyrrolo aminoimidazoles; sponge clathria ... See more keywords
Procerolides A-B from Microcionidae marine sponge Clathria procera: Anti-inflammatory macrocylic lactones with selective cyclooxygenase-2 attenuation properties.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104663
Abstract: Cyclooxygenase-2 has been recognized to catalyze the formation of inflammatory prostaglandins from arachidonic acid. Attenuation potential against cyclooxygenase-2 coupled with greater anti-inflammatory selectivity index were contemplated to be vital indicators to assess anti-inflammatory activities of… read more here.
Keywords: anti inflammatory; cyclooxygenase; attenuation; marine sponge ... See more keywords
New cytotoxic polyacetylene amides from the Egyptian marine sponge Siphonochalina siphonella.
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DOI: 10.1016/j.fitote.2020.104511
Abstract: Four new polyacetylene amides, siphonellamides A-D (1-4), and one new fatty amide, siphonellamide E (5), together with a known indole fatty amide (6) and callyspongamide A (7), were isolated from the Red Sea marine sponge… read more here.
Keywords: siphonochalina siphonella; marine sponge; sponge siphonochalina; polyacetylene amides ... See more keywords
Anti-mycobacterial haliclonadiamine alkaloids from the Okinawan marine sponge Haliclona sp. collected at Iriomote Island
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DOI: 10.1016/j.phytol.2018.05.028
Abstract: Abstract Two new haliclonadiamine derivatives, halichondriamine C (1) and 1-epi-halichondriamine C (2), were isolated from the Okinawan marine sponge Haliclona sp. together with known haliclonadiamine (3) and papuamine (4). The structures of 1 and 2… read more here.
Keywords: haliclonadiamine; okinawan marine; sponge haliclona; marine sponge ... See more keywords
Anti-MRSA actinomycins D1-D4 from the marine sponge-associated Streptomyces sp. LHW52447
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DOI: 10.1016/j.tet.2018.08.023
Abstract: Abstract Actinomycins D1−D4 (1–4), four new D-type actinomycin analogues, were isolated from the fermentation broth of a strain of marine sponge-associated Streptomyces sp. LHW52447, together with actinomycin D (5). The structures of 1−4 were determined… read more here.
Keywords: anti mrsa; streptomyces lhw52447; sponge associated; associated streptomyces ... See more keywords
Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar.
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DOI: 10.1021/acs.jnatprod.2c00094
Abstract: Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole-derived metabolites. An in-house library of bromopyrrole alkaloids previously isolated from A. dispar… read more here.
Keywords: bromopyrrole; sponge agelas; feature based; molecular networking ... See more keywords
Identification of Anthelmintic Bishomoscalarane Sesterterpenes from the Australian Marine Sponge Phyllospongia bergquistae and Structure Revision of Phyllolactones A-D.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00229
Abstract: High-throughput screening of the NatureBank marine extract library (7616 samples) identified an extract derived from the Australian marine sponge Phyllospongia bergquistae with activity against Hemonchus contortus (barber's pole worm), an economically important parasitic nematode. Bioassay-guided… read more here.
Keywords: sponge phyllospongia; bishomoscalarane sesterterpenes; australian marine; marine sponge ... See more keywords
Neopetrosins A-D and Haliclorensin D, Indole-C-Mannopyranosides and a Diamine Alkaloid Isolated from the South China Sea Marine Sponge Neopetrosia chaliniformis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00292
Abstract: Four new indole-C-mannopyranoside alkaloids, neopetrosins A-D (1-4), together with one new diamine alkaloid, haliclorensin D (6), were isolated from the marine sponge Neopetrosia chaliniformis collected off Xisha Island in the South China Sea. Their structures… read more here.
Keywords: neopetrosia chaliniformis; diamine alkaloid; china sea; south china ... See more keywords
Zamamiphidins B and C, Manzamine-Related Alkaloids from an Amphimedon sp. Marine Sponge Collected in Okinawa.
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DOI: 10.1021/acs.jnatprod.2c00395
Abstract: Zamamiphidins B (1) and C (2), two new manzamine-related alkaloids with an unprecedented fused diazahexacyclic ring system, were isolated from an Amphimedon sp. marine sponge collected in Okinawa. The structures of zamamiphidins B (1) and… read more here.
Keywords: collected okinawa; amphimedon marine; manzamine related; related alkaloids ... See more keywords