Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition
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DOI: 10.1039/c8nj01277f
Abstract: Three cinchona derivatives have shown remarkable activity to catalyze the aza-Markovnikov addition reaction of N-heterocycles to vinyl esters. The synthesis of aza-Markovnikov adducts possessing valuable biological activity was thoroughly optimized. By studying the ratio of… read more here.
Keywords: markovnikov addition; derivatives sustainable; aza markovnikov; cinchona derivatives ... See more keywords
Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives
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DOI: 10.3390/ma15051975
Abstract: An enzymatic route for phosphorous-carbon- bond formation is developed by discovering new promiscuous activity of lipase. This biocatalytic transformation of phosphorous-carbon- bond addition leads to biologically and pharmacologically relevant α-acyloxy phosphonates with methyl group in… read more here.
Keywords: phosphites vinyl; vinyl esters; lipase; markovnikov addition ... See more keywords