Bone: Bone marrow adipocytes in 3D
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2018.31
Abstract: Culturing bone marrow stromal cells on 3D silk scaffolds supports their proliferation and adipogenesis, while minimizing the activation of inflammatory pathways. Therefore, differentiation of bone marrow adipocytes in 3D culture might provide a more representative… read more here.
Keywords: bone; bone bone; marrow adipocytes; bone marrow ... See more keywords
Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-1645
Abstract: Leukemia cells in the bone marrow must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen availability. Thus, targeting metabolic abnormalities in leukemia cells… read more here.
Keywords: leukemia cells; bone; cells bone; marrow adipocytes ... See more keywords
Stem cell factor: the bridge between bone marrow adipocytes and hematopoietic cells
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.224188
Abstract: White adipocytes serve as an energy reservoir to store excessive calories in the form of lipid droplets and protect other tissues or organs from ectopic lipid accumulation. Brown adipocytes express uncoupling protein 1 and are… read more here.
Keywords: bridge bone; cell factor; stem cell; factor bridge ... See more keywords
Leukemia cells remodel marrow adipocytes via TRPV4-dependent lipolysis.
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.225763
Abstract: Remodeling of adipocyte morphology and function plays a critical role in prostate cancer development. We previously reported that leukemia cells secrete growth differentiation factor 15 (GDF15)，which remodels the residual bone marrow (BM) adipocytes into small… read more here.
Keywords: remodel marrow; leukemia cells; gdf15; marrow adipocytes ... See more keywords
Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.770705
Abstract: Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes,… read more here.
Keywords: bone; adipocytes critical; critical player; marrow adipocytes ... See more keywords
Toward Marrow Adipocytes: Adipogenic Trajectory of the Bone Marrow Stromal Cell Lineage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.882297
Abstract: Bone marrow contains precursor cells for osteoblasts and adipocytes in the stromal compartment. Bone marrow adipose tissue (BMAT) is an important constituent of the bone marrow that is particularly abundant in adults. BMAT is composed… read more here.
Keywords: cell; bone marrow; marrow; marrow adipocytes ... See more keywords
Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.902033
Abstract: Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty… read more here.
Keywords: bone metastasis; bone marrow; bone; marrow adipocytes ... See more keywords
Bone Marrow Adipocytes Contribute to Tumor Microenvironment-Driven Chemoresistance via Sequestration of Doxorubicin
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102737
Abstract: Simple Summary Despite substantial progress and effort, the clinical efficacy of chemotherapy remains suboptimal due to chemoresistance, which is partly attributed to adipocytes in the tumor microenvironment. Adipocytes, major stromal cells in the bone marrow,… read more here.
Keywords: microenvironment; bone marrow; marrow; marrow adipocytes ... See more keywords
ApoA1 Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094834
Abstract: In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized ApoA1 knockout mice. APOA1 is a central regulator of high-density lipoprotein… read more here.
Keywords: bone marrow; bone; marrow; marrow adipocytes ... See more keywords