Moderate‐To‐Severe Bone Marrow Fibrosis Is an Independent Risk Factor For Myelodysplastic Neoplasms Patients With Increased Blasts
Sign Up to like & getrecommendations! Published in 2025 at "Hematological Oncology"
DOI: 10.1002/hon.70043
Abstract: This study, including 412 patients newly diagnosed with myelodysplastic neoplasm (MDS), investigated the clinical, molecular, and prognostic features of MDS with moderate‐to‐severe bone marrow fibrosis (MF). Among the patients with MDS, 347 (84%) had MF… read more here.
Keywords: moderate severe; fibrosis; severe bone; patients mds ... See more keywords
Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN
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DOI: 10.1007/s00784-024-06008-3
Abstract: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of… read more here.
Keywords: bone marrow; resection; bone; resection margins ... See more keywords
Impact of bone marrow fibrosis on outcomes of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
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DOI: 10.1038/s41409-024-02402-3
Abstract: Bone marrow fibrosis (BMF) of unknown etiology was common in hematological malignancies, but its prognostic value for acute myeloid leukemia (AML) is unclear. We interrogated data from 532 newly diagnosed subjects with AML receiving allogeneic… read more here.
Keywords: bone marrow; cell; marrow fibrosis; transplantation ... See more keywords
Immune thrombocytopenia is associated with persistently deranged fibrosis-related seromarker profiles but low bone marrow fibrosis grades: A 2-year observational study on thrombopoietin receptor agonist treatment
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DOI: 10.1080/09537104.2017.1411586
Abstract: Abstract Bone marrow (BM) fibrosis is a potential side effect of thrombopoietin receptor agonist (TPO-RA) treatment. We aimed to investigate stromal seromarker profiles and growth factors in order to elucidate pathogenic and dynamic aspects of… read more here.
Keywords: marrow fibrosis; fibrosis; treatment; thrombopoietin receptor ... See more keywords
Reticulin-Free Quantitative Assessment of Bone Marrow Fibrosis in Myeloproliferative Neoplasms; Time to Sell the Family Silver?
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DOI: 10.1182/blood-2024-202336
Abstract: Estimation of bone marrow fibrosis is central to the evaluation of patients with myeloproliferative neoplasms (MPN). However, European consensus criteria for fibrosis evaluation (MF grades 0-3) are subjective and fail to capture heterogeneity across fibrosis… read more here.
Keywords: fibrosis; reticulin; model; bone ... See more keywords
Does Bone Marrow Fibrosis Play a Role in the Prognostication of Newly Diagnosed Polycythemia Vera Patients
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DOI: 10.1182/blood.v130.suppl_1.4184.4184
Abstract: According to the WHO 2016 revised classification of myeloproliferative disorders, bone marrow biopsy is included among the major criteria for the diagnosis of policythemia vera (PV). However, the prognostic role of marrow fibrosis at baseline… read more here.
Keywords: marrow fibrosis; consultancy speakers; speakers bureau; consultancy ... See more keywords
Bone marrow fibrosis associated with long-term imatinib therapy: resolution after switching to a second-generation TKI.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018027516
Abstract: Bone marrow fibrosis may be a late reversible toxicity of high-dose imatinib therapy in chronic myeloid leukemia. read more here.
Keywords: marrow fibrosis; imatinib therapy; bone marrow;
Coexisting of bone marrow fibrosis, dysplasia and an X chromosomal abnormality in chronic neutrophilic leukemia with CSF3R mutation: a case report and literature review
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DOI: 10.1186/s12885-018-4236-6
Abstract: BackgroundChronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) with less than 40 cases of patients being reported or clinically suspected meeting with 2008 World Health Organization (“WHO”) diagnostic criteria. The current diagnosis of… read more here.
Keywords: marrow fibrosis; bone marrow; csf3r; mutation ... See more keywords
Efficacy of BTI615 on malignant cells expansion and bone marrow fibrosis in a myelofibrosis mice model.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.6572
Abstract: 6572 Background: Due to the limitation of Janus kinase inhibitors and allogeneic transplant, critical unmet needs are remained in myelofibrosis (MF) patients, particularly for those with cytopenias, non-response or intolerance issues. Novel therapeutic avenues could… read more here.
Keywords: bone marrow; malignant cells; bone; marrow fibrosis ... See more keywords
Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update
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DOI: 10.3343/alm.2022.42.3.299
Abstract: Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring… read more here.
Keywords: syndromes bone; bone marrow; myelodysplastic syndromes; patients mds ... See more keywords
Bone Marrow Fibrosis at Diagnosis and during the Course of Disease Is Associated with TP53 Mutations and Adverse Prognosis in Primary Myelodysplastic Syndrome
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DOI: 10.3390/cancers14122984
Abstract: Simple Summary To understand the role of bone marrow fibrosis and its molecular changes in myelodysplastic syndrome, we retrospectively analyzed data from 814 patients. Older age, lower hemoglobin, unfavorable karyotype and higher BM blast were… read more here.
Keywords: myelodysplastic syndrome; prognosis; diagnosis; bone marrow ... See more keywords