Total marrow irradiation for hematopoietic malignancies using volumetric modulated arc therapy: A review of treatment planning studies☆☆☆
Sign Up to like & getrecommendations! Published in 2019 at "Physics and Imaging in Radiation Oncology"
DOI: 10.1016/j.phro.2019.08.001
Abstract: Total Marrow Irradiation (TMI) has been introduced in the management of hematopoietic malignancies with the aim of reducing toxicities induced by total body irradiation. TMI is one of the most challenging planning and delivery techniques… read more here.
Keywords: irradiation; total marrow; treatment planning; marrow irradiation ... See more keywords
Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide: A prospective study
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DOI: 10.1182/blood-2025-7738
Abstract: Introduction Post-transplant cyclophosphamide (PTCy) has nearly revolutionized the field of haploidentical hematopoietic cell transplantation (Haplo-HCT). The original protocol employed a non-myeloablative approach; however, the ideal conditioning regimen for haplo-HCT has not yet been established. Here,… read more here.
Keywords: conditioning regimen; haplo hct; marrow irradiation; study ... See more keywords
Total marrow irradiation in hematopoietic stem cell transplantation for hematologic malignancies
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DOI: 10.3389/fmed.2023.1155954
Abstract: Total body irradiation (TBI) has been an essential component of the conditioning regimen in hematopoietic cell transplantation for many years. However, higher doses of TBI reduce disease relapse at the expense of more significant toxicities.… read more here.
Keywords: cell transplantation; marrow irradiation; total marrow; irradiation ... See more keywords
Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.941814
Abstract: Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed… read more here.
Keywords: orthogonal collimator; sparse orthogonal; marrow irradiation; novel sparse ... See more keywords